Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
20000 | - |
1 * 57000 + 1 * 20000, SDS-PAGE | Mus musculus |
57000 | - |
1 * 57000 + 1 * 20000, SDS-PAGE | Mus musculus |
63000 | - |
predicted from amino acid sequence | Mus musculus |
75000 | - |
gel filtration | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | the enzyme localizes to capillaries and sinusoids in most organs and in lung to larger vessels as well | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene C4 + H2O | - |
Mus musculus | leukotriene D4 + L-glutamate | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | 1 * 57000 + 1 * 20000, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
gamma-glutamyl leukotrienase | - |
Mus musculus |
GGL | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | gamma-glutamyl leukotrienase-deficient mice show leukotriene C4 accumulation and significantly more airway hyperreponsiveness than wild-type mice in the experimental asthma | Mus musculus |
physiological function | in vivo gamma-glutamyl leukotrienase, and notgamma-glutamyl transpeptidase, is primarily responsible for conversion of leukotriene C4 to leukotriene D4. The enzyme plays an important role in inflammatory processes | Mus musculus |