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Literature summary for 3.4.19.14 extracted from
- gamma-Glutamyl leukotrienase cleavage of leukotriene C4 (2000), Adv. Exp. Med. Biol., 469, 301-306.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acivicin | - |
Mus musculus |  |
| additional information | not inhibited by glutathione | Mus musculus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0022 | - |
leukotriene C4 | pH and temperature not specified in the publication | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Mus musculus | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| ammonium sulfate precipitation and Sephadex G-150 gel filtration | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| lung | - |
Mus musculus | - |
| pancreas | - |
Mus musculus | - |
| small intestine | - |
Mus musculus | - |
| spleen | enzyme activity is highest in spleen | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene C4 + H2O | - |
Mus musculus | leukotriene D4 + L-glutamate | - |
? | |
| additional information | the enzyme does not cleave GSH, GSSG, S-(2,4-dinitrophenyl)glutathione, S-pentyl glutathione, gamma-glutamyl-4-nitroanilide, and gamma-glutamyl-4-methoxy-2-naphthylamide | Mus musculus | ? | - |
? | |
| S-decylglutathione + H2O | the Km for S-decyl glutathione is about 10fold higher than that for leukotriene C4 | Mus musculus | decan-1-ol + glutathione | - |
? | |
| S-heptylglutathione + H2O | - |
Mus musculus | heptan-1-ol + glutathione | - |
? | |
| S-hexyl glutathione + H2O | - |
Mus musculus | ? | - |
? | |
| S-nitrosylglutathione + H2O | - |
Mus musculus | nitrous acid + glutathione | - |
? | |
| S-nonylglutathione + H2O | - |
Mus musculus | nonan-1-ol + glutathione | - |
? | |
| S-octyl glutathione + H2O | - |
Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 65000-70000, sucrose velocity sedimentation | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| gamma-glutamyl leukotrienase | - |
Mus musculus |
| GGL | - |
Mus musculus |
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