Literature summary for 3.4.19.13 extracted from

Meredith, M.; Williams, G.
Intracellular glutathione cycling by gamma-glutamyl transpeptidase in tumorigenic and nontumorigenic cultured rat liver cells (1986), J. Biol. Chem., 261, 4986-4992.

Search for more literature for 3.4.19.13

Inhibitors

Inhibitors	Comment	Organism	Structure
acivicin	inhibition of gamma-glutamyltranspeptidase by acivicin causes extensive loss of intracellular glutathione from ARL-16T2 cells, which show a high level of gamma-glutamyl transpeptidase, but produces no effect on glutathione levels in ARL-15C1 cells, which show a low level of gamma-glutamyl transpeptidase. Acivicin treatment causes a transient increase in intracellular glutathione in the ARL-16T2 but not the ARL-15C1 cells	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
ARL-15C1 cell	nontumorigenic cell line, low level of gamma-glutamyltranspeptidase	Rattus norvegicus	-
ARL-16T2 cell	tumorigenic cell line, high level of gamma-glutamyl transpeptidase	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
gamma-glutamyl transpeptidase	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	inhibition of gamma-glutamyltranspeptidase by acivicin causes extensive loss of intracellular glutathione from ARL-16T2 cells, which show a high level of gamma-glutamyl transpeptidase, but produces no effect on glutathione levels in ARL-15C1 cells, which show a low level of gamma-glutamyl transpeptidase. Acivicin treatment causes a transient increase in intracellular glutathione in the ARL-16T2 but not the ARL-15C1 cells, further suggesting that the enzyme catalyzes intracellular glutathione recycling to supply cysteine for cellular functions in the tumorigenic ARL-16T2 cell line	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)