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Literature summary for 3.4.19.13 extracted from

  • Grillo, M.; Benet, L.
    Interaction of gamma-glutamyltranspeptidase with clofibryl-S-acyl-glutathione in vitro and in vivo in rat (2001), Chem. Res. Toxicol., 14, 1033-1040.
    View publication on PubMed
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Application

Application Comment Organism
medicine pharmacokinetics of S-(2-(4-chlorophenoxy)-2-methylpropanoyl)glutathione, i.e. clofibryl-S-acyl-glutathione, in urine of rats. gamma-Glutamyltransferase-mediated degradation of S-(2-(4-chlorophenoxy)-2-methylpropanoyl)glutathione leads primarily to the formation and excretion of clofibryl-N-acyl-cysteine products rather than the S-acyl-N-acetylcysteine conjugate. Clofibryl-S-acyl-glutathione is degraded to clofibryl-N-acyl-cysteinylglycine, clofibril-N-acyl-cysteine and their respective S-methylated products. The mercapturic acid conjugate is found as a minor product Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-(2-(4-chlorophenoxy)-2-methylpropanoyl)glutathione + H2O i.e. clofibril-S-acylglutathione Rattus norvegicus S-(2-(4-chlorophenoxy)-2-methylpropanoyl)-L-cysteinylglycine + L-glutamate the first step in the degradation of clofibril S-acylglutathione. complete degradation with formation of clofibryl-S-acyl-N-acetylcysteine and its disulfide, with no detection of clofibryl-S-acyl-cysteinylglycine thioester ?