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Literature summary for 3.4.19.1 extracted from

  • Gogliettino, M.; Riccio, A.; Balestrieri, M.; Cocca, E.; Facchiano, A.; DArco, T.M.; Tesoro, C.; Rossi, M.; Palmieri, G.
    A novel class of bifunctional acylpeptide hydrolases--potential role in the antioxidant defense systems of the Antarctic fish Trematomus bernacchii (2014), FEBS J., 281, 401-415.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.11
-
acetyl-Met-7-amido-4-methylcoumarin 50°C, pH 8 Trematomus bernacchii
0.12
-
acetyl-Ala-4-nitroanilide 15°C, pH 8 Trematomus bernacchii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
75000
-
SDS-PAGE Trematomus bernacchii
80000
-
SDS-PAGE Trematomus bernacchii
300000
-
gel filtration Trematomus bernacchii

Organism

Organism UniProt Comment Textmining
Trematomus bernacchii
-
-
-
Trematomus bernacchii V5QZ74
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Trematomus bernacchii
-
erythrocyte
-
Trematomus bernacchii
-
gill
-
Trematomus bernacchii
-
heart
-
Trematomus bernacchii
-
kidney
-
Trematomus bernacchii
-
liver
-
Trematomus bernacchii
-
liver strong expression Trematomus bernacchii
-
ovary
-
Trematomus bernacchii
-
ovary strong expression Trematomus bernacchii
-
spleen
-
Trematomus bernacchii
-
testis
-
Trematomus bernacchii
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-Ala-4-nitroanilide + H2O
-
Trematomus bernacchii acetyl-Ala + 4-nitroaniline
-
?
acetyl-Leu-4-nitroanilide + H2O
-
Trematomus bernacchii acetyl-Leu + 4-nitroaniline
-
?
acetyl-Met-7-amido-4-methylcoumarin + H2O
-
Trematomus bernacchii acetyl-Met + 7-amino-4-methylcoumarin
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 80000 Trematomus bernacchii
tetramer 4 * 75000 Trematomus bernacchii

Synonyms

Synonyms Comment Organism
acylpeptide hydrolase
-
Trematomus bernacchii
APEH-1
-
Trematomus bernacchii
apeH-2
-
Trematomus bernacchii

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
25 30
-
Trematomus bernacchii

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
10 20 enzyme retains 80% activity after 7h of incubation Trematomus bernacchii
37
-
complete inactivation after 5 h of incubation Trematomus bernacchii
37
-
residual activity halved after 5 h of incubation Trematomus bernacchii
50
-
half-life of a few min Trematomus bernacchii

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.014
-
acetyl-Ala-4-nitroanilide 50°C, pH 8 Trematomus bernacchii
0.03
-
acetyl-Met-7-amido-4-methylcoumarin 50°C, pH 8 Trematomus bernacchii
0.09
-
acetyl-Leu-4-nitroanilide 15°C, pH 8 Trematomus bernacchii
1.7
-
acetyl-Ala-4-nitroanilide 15°C, pH 8 Trematomus bernacchii
7.74
-
acetyl-Met-7-amido-4-methylcoumarin 50°C, pH 8 Trematomus bernacchii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Trematomus bernacchii

Expression

Organism Comment Expression
Trematomus bernacchii strong expression in liver up
Trematomus bernacchii strong expression in ovary up

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
4.72
-
acetyl-Met-7-amido-4-methylcoumarin 50°C, pH 8 Trematomus bernacchii
4.76
-
acetyl-Ala-4-nitroanilide 37°C, pH 8 Trematomus bernacchii