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Literature summary for 3.4.18.1 extracted from
- Characterization and expression of cathepsin B2 in Fasciola gigantica (2012), Exp. Parasitol., 132, 249-256.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Pichia pastoris | Fasciola gigantica |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Fasciola gigantica | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | enzyme is found in whole body extracts of metacercariae , newly excysted juveniles and 2 week-old juveniles, but not in 3, 4 week-old juveniles and adult flukes, with presence of cathepsin B2 only in the caecal epithelium of metacercariae, newly excysted juveniles and 2 week-old juveniles | Fasciola gigantica | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O | - |
Fasciola gigantica | benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin | - |
? |  |
| additional information | in addition, enzyme shows cysteine endopeptidase activity degrading gelatin, IgG and type I collagen | Fasciola gigantica | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cathepsin B2 | - |
Fasciola gigantica |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | cathepsin B2 is expressed only in early stages of the parasite and may be involved in digestion of host connective tissues and evasion of the host immune system during their penetration and migration | Fasciola gigantica |
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