Literature summary for 3.4.17.23 extracted from

Lu, C.L.; Wang, Y.; Yuan, L.; Li, Y.; Li, X.Y.
The angiotensin-converting enzyme 2/angiotensin (1-7)/Mas axis protects the function of pancreatic beta cells by improving the function of islet microvascular endothelial cells (2014), Int. J. Mol. Med., 34, 1293-1300.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Synonyms

Synonyms	Comment	Organism
ACE2	-	Mus musculus
angiotensin converting enzyme 2	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	ACE2 knockout mice are more susceptible than the wild-type mice to high-fat diet-induced beta cell dysfunction. The TUNEL-positive area of the pancreatic islets and the expression levels of IL-1beta and iNOS are markedly increased in the ACE2 knockout mice compared with their wild-type littermates. The Mas-silenced MS-1 cells are more sensitive to palmitate-induced dysfunction and apoptosis in vitro	Mus musculus
physiological function	ACE2/angiotensin (1-7)/Mas axis protects the function of pancreatic beta cells by improving the function of islet microvascular endothelial cells	Mus musculus

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Release 2023.1 (January 2023)