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Literature summary for 3.4.17.23 extracted from

  • Zhao, Y.; Yin, H.Q.; Yu, Q.T.; Qiao, Y.; Dai, H.Y.; Zhang, M.X.; Zhang, L.; Liu, Y.F.; Wang, L.C.; Liu, D.S.; Deng, B.P.; Zhang, Y.H.; Pang, C.M.; Song, H.D.; Qu, X.; Jiang, H.; Liu, C.X.; Lu, X.T.; Liu, B.; Gao, F.; Dong, B.
    ACE2 overexpression improves left ventricular remodeling and function in rats with myocardial infarction (2010), Hum. Gene Ther., 21, 1545-1554.
    View publication on PubMed
Search for more literature for 3.4.17.23

Application

Application Comment Organism
pharmacology ACE 2 is a potential therapeutic target in the treatment of heart failure Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
cloning of the enzyme utilizing the murine cytomegalovirus immediate early gene promoter, MCMV Pr, in an adenoviral vector for ACE2 overexpression in rats as a gene therapy model. overview Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information overexpression of ACE2 favorably affects the pathological process of left ventricular remodeling after myocardial infarction by inhibiting ACE activity, reducing AngII levels and upregulating Ang(1-7) expression Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell membrane
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin II + H2O Rattus norvegicus
-
 angiotensin(1-7) + L-Phe
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male Wistar-Kyoto rats
-

Source Tissue

Source Tissue Comment Organism Textmining
blood vessel
-
 Rattus norvegicus
-
coronary artery vascular walls and endothelium Rattus norvegicus
-
endothelium and vascular walls of coronary arteries Rattus norvegicus
-
heart
-
 Rattus norvegicus
-
macrophage
-
 Rattus norvegicus
-
myocardium
-
 Rattus norvegicus
-
myocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin II + H2O
-
 Rattus norvegicus angiotensin(1-7) + L-Phe
-
 ?
angiotensin II + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, detection of myocardial ACE2 activity by surface enhanced laser desorption lionization time of flight mass spectroscopy, SELDI-TOF-MS Rattus norvegicus angiotensin(1-7) + L-Phe i.e. Asp-Arg-Val-Tyr-Ile-His-Pro ?

Synonyms

Synonyms Comment Organism
ACE2
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function angiotensin II is a critical factor for stimulating cardiocyte hypertrophy, fibroblast proliferation and extracellular matrix production in left ventricular remodeling. ACE2 overexpression attenuates left ventricular myocardial fibrosis and improves left ventricular remodeling and systolic function, overview Rattus norvegicus