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Literature summary for 3.4.17.23 extracted from

  • Huang, M.L.; Li, X.; Meng, Y.; Xiao, B.; Ma, Q.; Ying, S.S.; Wu, P.S.; Zhang, Z.S.
    Upregulation of angiotensin-converting enzyme (ACE) 2 in hepatic fibrosis by ACE inhibitors (2010), Clin. Exp. Pharmacol. Physiol., 37, e1-e6.
    View publication on PubMed
Search for more literature for 3.4.17.23

Cloned(Commentary)

Cloned (Comment) Organism
ACE2 expression analysis by RT-PCR Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information ACE2 is insensitive to ACE inhibitors Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin II + H2O Rattus norvegicus
-
 angiotensin(1-7) + L-Phe
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
connective tissue
-
 Rattus norvegicus
-
hepatic stellate cell
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin II + H2O
-
 Rattus norvegicus angiotensin(1-7) + L-Phe
-
 ?
angiotensin II + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Rattus norvegicus angiotensin(1-7) + L-Phe i.e. Asp-Arg-Val-Tyr-Ile-His-Pro ?

Synonyms

Synonyms Comment Organism
ACE2
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus the enzyme expression is upregulated in case of induced liver fibrosis and is further upregulated by additional administration of ACE I inhibitor peptide, pGlu-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro, in hepatic stellate cells up

General Information

General Information Comment Organism
physiological function ACE 2 balances the status of the renin-angiotensin system by degrading angiotensin II and generating angiotensin-(1-7). ACE2 induces overexpression of connective tissue growth factor, which is inhibited by blockade of theMas receptor with A779, overview Rattus norvegicus