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Literature summary for 3.4.17.23 extracted from

  • Guy, J.L.; Jackson, R.M.; Jensen, H.A.; Hooper, N.M.; Turner, A.J.
    Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis (2005), FEBS J., 272, 3512-3520.
    View publication on PubMed
Search for more literature for 3.4.17.23

Protein Variants

Protein Variants Comment Organism
H345A no activity with (7-methoxycoumarin-4-yl)acetyl-APK-2,4-dinitrophenyl Homo sapiens
H345L no activity with (7-methoxycoumarin-4-yl)acetyl-APK-2,4-dinitrophenyl Homo sapiens
H505A 1.5% of wild-type activity with (7-methoxycoumarin-4-yl)acetyl-APK-2,4-dinitrophenyl as substrate Homo sapiens
H505L no activity with (7-methoxycoumarin-4-yl)acetyl-APK-2,4-dinitrophenyl Homo sapiens
R169Q as active as wild-type enzyme with (7-methoxycoumarin-4-yl)acetyl-APK-2,4-dinitrophenyl as substrate Homo sapiens
R273K no activity with (7-methoxycoumarin-4-yl)acetyl-APK-2,4-dinitrophenyl Homo sapiens
R273Q no activity with (7-methoxycoumarin-4-yl)acetyl-APK-2,4-dinitrophenyl Homo sapiens
R514Q about 10% of wild-type activity with (7-methoxycoumarin-4-yl)acetyl-APK-2,4-dinitrophenyl as substrate Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)acetyl-APK-2,4-dinitrophenyl + H2O
-
 Homo sapiens (7-methoxycoumarin-4-yl)acetyl-AP + N6-(2,4-dinitrophenyl)-L-lysine
-
 ?