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Literature summary for 3.4.17.21 extracted from

  • Ferraris, D.V.; Majer, P.; Ni, C.; Slusher, C.E.; Rais, R.; Wu, Y.; Wozniak, K.M.; Alt, J.; Rojas, C.; Slusher, B.S.; Tsukamoto, T.
    delta-Thiolactones as prodrugs of thiol-based glutamate carboxypeptidase II (GCPII) inhibitors (2014), J. Med. Chem., 57, 243-247.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
2-(3-mercaptopropyl)pentanedioic acid in rat liver microsomes, 2-(3-mercaptopropyl)pentanedioic acid is gradually produced from 3-(2-oxotetrahydro-thiopyran-3-yl)propionic acid, a thiolactone derived from the compound. 2-(3-Mercaptopropyl)pentanedioic acid is detected in plasma at concentrations well above its IC50 value for GCPII following oral administration of 3-(2-oxotetrahydro-thiopyran-3-yl)propionic acid in rats Rattus norvegicus
3-(2-oxotetrahydro-thiopyran-3-yl)propionic acid prodrug of inhibitor 2-(3-mercaptopropyl)pentanedioic acid Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.002
-
 pH not specified in the publication, temperature not specified in the publication Rattus norvegicus 3-(2-oxotetrahydro-thiopyran-3-yl)propionic acid