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Literature summary for 3.4.17.21 extracted from

  • Robinson, M.B.; Blakely, R.D.; Couto, R.; Coyle, J.T.
    Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate (1987), J. Biol. Chem., 262, 14498-14506.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline 1 mM, 90% inhibition Rattus norvegicus
2-oxoglutarate 0.1 mM, 46% inhibition Rattus norvegicus
Ala-Glu 0.0061 mM, 50% inhibition Rattus norvegicus
Asp-Ala 0.1 mM, 26% inhibition Rattus norvegicus
Asp-Asp 0.1 mM, 42% inhibition Rattus norvegicus
Asp-Glu 0.0024 mM, 50% inhibition Rattus norvegicus
Asp-Phe 0.1 mM, 22% inhibition Rattus norvegicus
aspartate 0.1 mM, 42% inhibition Rattus norvegicus
bestatin 0.29 mM, 79% inhibition Rattus norvegicus
Cd2+
-
Rattus norvegicus
Cu2+
-
Rattus norvegicus
cysteate 0.1 mM, 40% inhibition Rattus norvegicus
cysteine sulfinate 0.1 mM, 42% inhibition Rattus norvegicus
D-Glu-D-Glu 0.1 mM, 50% inhibition Rattus norvegicus
dithiothreitol 1 mM, 94.8% inhibition Rattus norvegicus
EDTA 1 mM, 96.3% inhibition Rattus norvegicus
EGTA 1 mM, 92% inhibition Rattus norvegicus
Fe3+
-
Rattus norvegicus
gamma-Glu-Glu 0.0095 mM, 50% inhibition Rattus norvegicus
Glu-Asp 0.1 mM, 27% inhibition Rattus norvegicus
Glu-Glu 0.00075 mM, 50% inhibition Rattus norvegicus
Glu-Glu-Glu 0.062 mM, 50% inhibition Rattus norvegicus
glutathione i.e. gamma-Glu-Cys-Gly, 0.019 mM, 50% inhibition Rattus norvegicus
Gly-Glu 0.008 mM, 50% inhibition Rattus norvegicus
Gly-Gly-Glu 0.00098 mM, 50% inhibition Rattus norvegicus
Ibotenate 0.1 mM, 45% inhibition Rattus norvegicus
iodoacetate 1 mM, 38% inhibition Rattus norvegicus
L-2-Amino-4-phosphonobutanoate 0.1 mM, 37% inhibition Rattus norvegicus
L-Glu 0.032 mM, 50% inhibition Rattus norvegicus
additional information not inhibitory are pepstatin, iodoacetamide, amastatin Rattus norvegicus
N-Acetyl-Asp-Gln 0.1 mM, 49% inhibition Rattus norvegicus
N-Acetyl-Asp-Glu-Asp 0.1 mM, 49% inhibition Rattus norvegicus
N-Acetyl-Asp-Ser-Gly 0.1 mM, 37% inhibition Rattus norvegicus
N-Acetyl-Glu-Asp 0.036 mM, 50% inhibition Rattus norvegicus
N-Acetyl-Glu-Glu 0.00031 mM, 50% inhibition Rattus norvegicus
N-acetyl-L-Asp 0.1 mM, 38% inhibition Rattus norvegicus
N-Acetyl-L-Asp-L-Glu 0.00054 mM, 50% inhibition Rattus norvegicus
N-acetyl-L-Glu 0.058 mM, 50% inhibition Rattus norvegicus
Phe-Glu 0.077 mM, 50% inhibition Rattus norvegicus
PO43-
-
Rattus norvegicus
puromycin 0.5 mM, 55% inhibition Rattus norvegicus
pyroglutamate 0.1 mM, 27% inhibition Rattus norvegicus
quinolinate 0.1 mM, 41% inhibition Rattus norvegicus
Quisqualic acid 0.00048 mM, 50% inhibition Rattus norvegicus
Serine O-sulfate 0.042 mM, 50% inhibition Rattus norvegicus
SO42-
-
Rattus norvegicus
Tyr-Glu 0.1 mM, 45% inhibition Rattus norvegicus
Val-Glu-Glu 0.036 mM, 50% inhibition Rattus norvegicus
Zn2+
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
540
-
N-Acetyl-L-Asp-L-Glu
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Br- 2 mM, activation Rattus norvegicus
Ca2+ activation Rattus norvegicus
Cl- 2 mM, activation Rattus norvegicus
Co2+ activation Rattus norvegicus
F- 100 mM, 20% of the activity compared to Cl- Rattus norvegicus
I- 2 mM, activation Rattus norvegicus
Mg2+ activation Rattus norvegicus
Mn2+ activation Rattus norvegicus
NO3- 2 mM , activation Rattus norvegicus
Sr2+ activation Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain forebrain Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
assay method Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-Acetyl-L-Asp-L-Glu + H2O
-
Rattus norvegicus N-Acetyl-L-Asp + L-Glu
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
Rattus norvegicus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
25 80 more than 50% of maximal activity in this range Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6 7.4 more than 50% of maximal activity in this range Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00031
-
N-Acetyl-Glu-Glu
-
Rattus norvegicus
0.00054
-
N-Acetyl-L-Asp-L-Glu
-
Rattus norvegicus
0.00075
-
Glu-Glu
-
Rattus norvegicus
0.00098
-
Gly-Gly-Glu
-
Rattus norvegicus
0.0024
-
Asp-Glu
-
Rattus norvegicus
0.008
-
Gly-Glu
-
Rattus norvegicus
0.019
-
glutathione i.e. gamma-Glu-Cys-Gly Rattus norvegicus
0.036
-
N-Acetyl-Glu-Asp
-
Rattus norvegicus
0.036
-
Val-Glu-Glu
-
Rattus norvegicus
0.042
-
Serine O-sulfate
-
Rattus norvegicus
0.058
-
N-acetyl-L-Glu
-
Rattus norvegicus
0.061
-
Ala-Glu
-
Rattus norvegicus
0.062
-
Glu-Glu-Glu
-
Rattus norvegicus
0.077
-
Phe-Glu
-
Rattus norvegicus
0.095
-
gamma-Glu-Glu
-
Rattus norvegicus
0.1
-
D-Glu-D-Glu
-
Rattus norvegicus