Cloned (Comment) | Organism |
---|---|
expression in BHK cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
R302Q | specific activity with hippuryl-Arg is approximately half that of either recombinant wild-type enzyme or plasma derived enzymeR302Q-TAFIa is not proteolyzed by thrombin, even when 10times higher concentrations of thrombin/thrombomodulin are used | Homo sapiens |
General Stability | Organism |
---|---|
inactivation of TAFIa is the result of the conformational instability of TAFIa and not a direct result of proteolysis of TAFIa. It is possible that the conformational changes that take place as a result of the conformational instability make the inactivated 35800 Da enzyme form more susceptible to proteolysis. epsilon-Aminocaproic acid stabilizes | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60000 | - |
x * 60000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fibrin + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme and mutant enzyme R302Q | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fibrin + H2O | - |
Homo sapiens | ? | - |
? | |
hippuryl-Arg + H2O | - |
Homo sapiens | hippuric acid + Arg | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 60000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
TAFI | - |
Homo sapiens |