Activating Compound | Comment | Organism | Structure |
---|---|---|---|
thrombin | - |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
antithrombomodulin antibody | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
65000 | - |
Western blot analysis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
OPN-R + H2O | Homo sapiens | osteopontin (OPN) gets activated by thrombin resulting in OPN-R. OPN-R is subsequently inactivated by CPB generating OPN-L | OPN-L + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
synoviocyte | fibroblast-like synoviocytes | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
OPN-R + H2O | osteopontin (OPN) gets activated by thrombin resulting in OPN-R. OPN-R is subsequently inactivated by CPB generating OPN-L | Homo sapiens | OPN-L + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PcpB | - |
Homo sapiens |
thrombin-activatable fibrinolysis inhibitor | - |
Homo sapiens |
thrombin-activatable procarboxypeptidase B | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | thrombin-activatable CPB plays a central homeostatic role in rheumatoid arthritis by regulating neutrophil viability and reducing synoviocyte adhesion | Homo sapiens |