Activating Compound | Comment | Organism | Structure |
---|---|---|---|
thrombin | - |
Homo sapiens | |
Thrombomodulin | HT1080 cells mediate activation of TAFI in plasma in the presence of soluble-type thrombomodulin through cell-dependent prothrombin activation. HT1080 cells stably expressing thrombomodulin mediate plasma TAFI activation without added soluble thrombomodulin | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
SDS-PAGE, activated form | Homo sapiens |
58000 | - |
SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
purified by chromatography on Q-Sepharose Fast Flow, Heparin-Sepharose CL-6B, Sephacryl S-300, and plasminogen-Sepharose columns | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HT-1080 cell | - |
Homo sapiens | - |
plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Hippuryl-L-Arg + H2O | - |
Homo sapiens | Hippuric acid + L-Arg | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carboxypeptidase B | - |
Homo sapiens |
TAFI | possesses carboxypeptidase B-like activity | Homo sapiens |
thrombin-activatable fibrinolysis inhibitor | possesses carboxypeptidase B-like activity | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | thrombomodulin suppresses pericellular fibrinolysis and plasma-induced tumor cell invasion, which is mediated by plasma TAFI activation | Homo sapiens |