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Literature summary for 3.4.17.17 extracted from
- Miniaturization and validation of a sensitive multiparametric cell-based assay for the concomitant detection of microtubule-destabilizing and microtubule-stabilizing agents (2006), J. Biomol. Screen., 11, 377-389.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | cell-based assay for anti-microtubule compounds suitable for automation, based on the substrate properties of the tubulin-modifying enzymes TCP and TTL involved in the tubulin tyrosination cycle. Assay allows the identification, in a single screening campaign, of both microtubule-destabilizing and microtubule-stabilizing agents | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-tubulin + H2O | carboxy-terminal tyrosine of alpha-tubulin is removed by TCP and readded by tubulin tyrosine ligase (TTL) | Homo sapiens | detyrosinated tubulin + Tyr | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TCP | - |
Homo sapiens |
| tubulin carboxypeptidase | - |
Homo sapiens |
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