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Literature summary for 3.4.17.17 extracted from

  • Utreras, E.; Jimenez-Mateos, E.M.; Contreras-Vallejos, E.; Tortosa, E.; Perez, M.; Rojas, S.; Saragoni, L.; Maccioni, R.B.; Avila, J.; Gonzalez-Billault, C.
    Microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosination (2008), Dev. Neurosci., 30, 200-210.
    View publication on PubMed
Search for more literature for 3.4.17.17

Activating Compound

Activating Compound Comment Organism Structure
additional information MAP1B heavy chain may enhance TTL activity. Interaction between microtubule-associated protein 1B and TTL is not regulated by MAP1B phosphorylation Mus musculus

Application

Application Comment Organism
additional information interaction between MAP1B and TTL may have relevance to the dynamics of microtubule assembly and thus neuronal migration and axonogenesis Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of TTL together with different MAP1B constructs (full-length MAP1B, MAP1B heavy chain and MAP1B light chain 1) in COS-7 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information MAP1B mutant, loss of MAP1B is deleterious for the efficient tyrosination of microtubules both in vitro and in vivo Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information neurons lacking MAP1B, when exposed to drugs that reversibly depolymerize microtubules, do not fully recover tyrosinated microtubules upon drug removal. The microtubule-depolymerizing drug nocodazole does not affect MAP1B-TTL interaction. GST-TTL is able to pull down MAP1B, whereas GST itself does not Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microtubule
-
 Mus musculus 5874
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
 Mus musculus
-
neuroblastoma cell N2a cells, high level of MAP1B expression Mus musculus
-
neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-tubulin + H2O MAP1B regulates tyrosination of alpha-tubulin in neuronal microtubules Mus musculus detyrosinated tubulin + Tyr
-
 ?

Synonyms

Synonyms Comment Organism
MAP1B
-
 Mus musculus
microtubule-associated protein 1B
-
 Mus musculus