Literature summary for 3.4.17.17 extracted from

Fonrose, X.; Ausseil, F.; Soleilhac, E.; Masson, V.; David, B.; Pouny, I.; Cintrat, J.C.; Rousseau, B.; Barette, C.; Massiot, G.; Lafanechere, L.
Parthenolide inhibits tubulin carboxypeptidase activity (2007), Cancer Res., 67, 3371-3378.

Search for more literature for 3.4.17.17

Application

Application	Comment	Organism
medicine	TCP may be a target for developing novel therapeutic strategies against advanced stages of cancers. Inhibitors of TCP, by reversing abnormal detyrosinated tubulin accumulation in tumor cells, may impair tumor progression	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
cnicin	-	Homo sapiens
ID3	monoclonal antibody directed against the active site of TTL	Homo sapiens
additional information	dihydroparthenolide, costunolide and sulindac have no effect on TCP activity. Compounds from Vernonia perrottetii show potent TCP inhibitory activity	Homo sapiens
parthenolide	efficiently inhibits. Inhibition of TCP activity is independent of NF-kappaB inhibition; inhibition of tubulin carboxypeptidase could be one of the mechanisms underlying the anticancer properties of parthenolide	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
alpha-tubulin + H2O	-	Homo sapiens	detyrosinated tubulin + Tyr	-	?

Synonyms

Synonyms	Comment	Organism
TCP	-	Homo sapiens
tubulin carboxypeptidase	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)