Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P48052 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | in silico conversion of zymogen into the primary cleavage state using available X-ray structures to investigate its spontaneous dissociation process of the prosegment from its associated enzyme domain using steered molecular dynamics simulation. The cleavage substantially destabilizes most of the hydrogen bonds at the prosegment-enzyme interface. During prosegment unbinding, the enzyme shows first rupture in the globular domain and then in the connecting segment | Homo sapiens |