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Literature summary for 3.4.17.13 extracted from

  • Hoyland, C.N.; Aldridge, C.; Cleverley, R.M.; Duchene, M.C.; Minasov, G.; Onopriyenko, O.; Sidiq, K.; Stogios, P.J.; Anderson, W.F.; Daniel, R.A.; Savchenko, A.; Vollmer, W.; Lewis, R.J.
    Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition (2014), Structure, 22, 949-960.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.17.13

Inhibitors

Inhibitors Comment Organism Structure
EDTA isoform LcdB is inactive in the presence of EDTA Streptococcus pneumoniae

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ isoform LcdB is active in the presence of Zn2+ ions and inactive in the presence of EDTA Streptococcus pneumoniae

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae Q8DQQ1
-
-
Streptococcus pneumoniae ATCC BAA-255 Q8DQQ1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala-D-Gln-L-Lys-D-Ala + H2O
-
 Streptococcus pneumoniae L-Ala-D-Gln-L-Lys + D-Ala
-
 ?
L-Ala-D-Gln-L-Lys-D-Ala + H2O
-
 Streptococcus pneumoniae ATCC BAA-255 L-Ala-D-Gln-L-Lys + D-Ala
-
 ?
additional information no activity with substrate L-Ala-D-Gln-L-Lys-L-Ala Streptococcus pneumoniae ?
-
 ?
additional information no activity with substrate L-Ala-D-Gln-L-Lys-L-Ala Streptococcus pneumoniae ATCC BAA-255 ?
-
 ?
muropeptides + H2O
-
 Streptococcus pneumoniae ? incubation of isoform LcdB with peptidoglucan from the LcdB mutant strain leads to almost quantitative digestion of peptidoglucan tetrapeptides with a carboxy-terminal D-Ala producing the tripeptides ?
muropeptides + H2O
-
 Streptococcus pneumoniae ATCC BAA-255 ? incubation of isoform LcdB with peptidoglucan from the LcdB mutant strain leads to almost quantitative digestion of peptidoglucan tetrapeptides with a carboxy-terminal D-Ala producing the tripeptides ?

Synonyms

Synonyms Comment Organism
LdcB
-
 Streptococcus pneumoniae
Spr0554
-
 Streptococcus pneumoniae

General Information

General Information Comment Organism
physiological function an isoform LdcB mutant strain lacked tripeptides and contains mainly tetrapeptides in its peptidoglucans Streptococcus pneumoniae