Literature summary for 3.4.17.12 extracted from

Lu, D.; Yao, Q.; Zhan, C.; Le-Meng, Z.; Liu, H.; Cai, Y.; Tu, C.; Li, X.; Zou, Y.; Zhang, S.
MicroRNA-146a promote cell migration and invasion in human colorectal cancer via carboxypeptidase M/src-FAK pathway (2017), Oncotarget, 8, 22674-22684 .

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Application

Application	Comment	Organism
diagnostics	expression is positively correlated with overall survival and negatively correlated with recurrence, lymph node invasion, and N stage in colorectal cancer	Homo sapiens
medicine	expression is positively correlated with overall survival and negatively correlated with recurrence, lymph node invasion, and N stage in colorectal cancer	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P14384	-	-

General Information

General Information	Comment	Organism
physiological function	both microRNA-146a-5p and carboxypeptidase M regulate Src and FAK expression, while the Src-FAK signaling pathway is associated with the migration and invasion of multiple tumor cells. The functional and mechanistic relationship of the miR-146a-5p/CPM/Src-FAK axis is demonstrated and its effect on the migration and invasion of colorectal cancer cells	Homo sapiens

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Release 2023.1 (January 2023)