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Literature summary for 3.4.17.12 extracted from

  • Denis, C.J.; Van Acker, N.; De Schepper, S.; De Bie, M.; Andries, L.; Fransen, E.; Hendriks, D.; Kockx, M.M.; Lambeir, A.M.
    Mapping of carboxypeptidase m in normal human kidney and renal cell carcinoma: expression in tumor-associated neovasculature and macrophages (2013), J. Histochem. Cytochem., 61, 218-235.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine tumor cells of renal cell carcinoma subtypes lose carboxypeptidase M expression upon dedifferentiation. There is a correlation between low carboxypeptidase M expression and tumor cell type. Carboxypeptidase M staining is intense on phagocytotic tumor-associated macrophages, and enzyme is also detected in the tumor-associated vasculature. Coexistence of carboxypeptidase M and the epidermal growth factor receptor is detected in papillary renal cell carcinoma Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
kidney broad distribution of enzyme along the renal tubular structures in the healthy kidney.Carboxypeptidase M is identified at the parietal epithelium beneath the Bowman's basement membrane and in glomerular mesangial cells. Capillaries, podocytes, and most interstitial cells are CPM negative Homo sapiens
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renal cell carcinoma cell tumor cells of renal cell carcinoma subtypes lose carboxypeptidase M expression upon dedifferentiation. There is a correlation between low carboxypeptidase M expression and tumor cell type. Carboxypeptidase M staining is intense on phagocytotic tumor-associated macrophages, and enzyme is also detected in the tumor-associated vasculature. Coexistence of carboxypeptidase M and the epidermal growth factor receptor is detected in papillary renal cell carcinoma Homo sapiens
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