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Literature summary for 3.4.17.11 extracted from
- Glutamate carboxypeptidase inhibition reduces the severity of chemotherapy-induced peripheral neurotoxicity in rat (2010), Neurotox. Res., 17, 380-391.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | glutamate carboxypeptidase inhibition is evident for a neuroprotective role in several chronic models of chemotherapy-induced peripheral neuropathy and claims an approach for the clinical treatment of this pathology | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | orally available glutamate carboxypeptidase inhibitor E2072 (commercial preparation) has a neuroprotective effect on three well-established animal models of chemotherapy. It improves the chemotherapy-induced nerve conduction velocity deficits | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glutamate carboxypeptidase | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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