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Literature summary for 3.4.17.10 extracted from
- Purification and characterization of enkephalin convertase, an enkephalin-synthesizing carboxypeptidase (1983), J. Biol. Chem., 258, 10950-10955.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Guanidinoethylmercaptosuccinic acid | - |
Bos taurus |  |
| [Leu5]Enkephalin-Arg6 | - |
Bos taurus | |
| [Met5]Enkephalin-Arg6 | - |
Bos taurus | |
| [Met5]Enkephalin-Lys6 | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.018 | - |
dansyl-Phe-Ala-Arg | pituitary | Bos taurus | |
| 0.019 | - |
dansyl-Phe-Ala-Arg | adrenal | Bos taurus | |
| 0.022 | - |
dansyl-Phe-Ala-Arg | brain | Bos taurus | |
| 0.029 | 0.031 | dansyl-Phe-Gly-Arg | - |
Bos taurus | |
| 0.058 | 0.062 | Dansyl-Pro-Ala-Arg | - |
Bos taurus | |
| 0.066 | 0.071 | dansyl-Phe-Leu-Arg | - |
Bos taurus | |
| 0.068 | 0.077 | dansyl-Phe-Ile-Arg | - |
Bos taurus | |
| 0.1 | 0.12 | Dansyl-Ala-Arg | - |
Bos taurus | |
| 0.16 | 0.18 | dansyl-Phe-Leu-Gly-Arg | - |
Bos taurus | |
| 0.34 | 0.49 | dansyl-Phe-Leu-Ala-Arg | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| secretory granule | chromaffin granules | Bos taurus | 30141 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
non-denaturing PAGE, gel filtration | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Bos taurus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal medulla | - |
Bos taurus | - |
| brain | - |
Bos taurus | - |
| hypophysis | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 120 | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Dansyl-Ala-Arg + H2O | - |
Bos taurus | Dansyl-Ala + Arg | - |
? | |
| Dansyl-Phe-Ala-Arg + H2O | - |
Bos taurus | Dansyl-Phe-Ala + Arg | - |
? | |
| Dansyl-Phe-Gly-Arg + H2O | - |
Bos taurus | Dansyl-Phe-Gly + Arg | - |
? | |
| Dansyl-Phe-Ile-Arg + H2O | - |
Bos taurus | Dansyl-Phe-Ile + Arg | - |
? | |
| dansyl-Phe-Leu-Ala-Arg + H2O | - |
Bos taurus | dansyl-Phe-Leu-Ala + Arg | - |
? | |
| Dansyl-Phe-Leu-Arg + H2O | - |
Bos taurus | Dansyl-Phe-Leu + Arg | - |
? | |
| dansyl-Phe-Leu-Gly-Arg + H2O | - |
Bos taurus | dansyl-Phe-Leu-Gly + Arg | - |
? | |
| Dansyl-Pro-Ala-Arg + H2O | - |
Bos taurus | Dansyl-Pro-Ala + Arg | - |
? | |
| enkephalin precursor + H2O | - |
Bos taurus | ? | - |
? | |
| additional information | - |
Bos taurus | ? | - |
? | |
| proinsulin tryptic peptides + H2O | - |
Bos taurus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 6 | - |
Bos taurus |
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