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Literature summary for 3.4.17.1 extracted from

  • Masuhara, M.; Sato, T.; Hada, N.; Hakeda, Y.
    Protective protein/cathepsin A down-regulates osteoclastogenesis by associating with and degrading NF-kappaB p50/p65 (2009), J. Bone Miner. Metab., 27, 46-56.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(R)-2-benzyl-3-nitropropanoic acid X-ray crystallography discloses that the nitro group well mimics the transition state occurred in the hydrolysis catalyzed by CPA, that is, an O,O'-bidentate coordination to the zinc ion and the two respective hydrogen bonds with Glu-270 and Arg-127. Because the nitro group is a planar species, (R)-2-benzyl-3-nitropropanoic acid is as a pseudo-transition-state analog inhibitor against CPA Bos taurus
(RS)-2-benzyl-3-nitropropanoic acid
-
Bos taurus
(RS)-2-isobutyl-3-nitropropanoic acid
-
Bos taurus
(S)-2-benzyl-3-nitropropanoic acid
-
Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
O-(trans-p-chlorocinnamoyl)-L-beta-phenyllactate + H2O
-
Bos taurus ?
-
?

Synonyms

Synonyms Comment Organism
carboxypeptidase a
-
Bos taurus
CPA
-
Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00015
-
(R)-2-benzyl-3-nitropropanoic acid
-
Bos taurus
0.00015
-
2-benzyl-3-nitropropanoic acid
-
Bos taurus
0.00079
-
(RS)-2-benzyl-3-nitropropanoic acid
-
Bos taurus
0.002
-
(RS)-2-isobutyl-3-nitropropanoic acid
-
Bos taurus
0.068
-
(S)-2-benzyl-3-nitropropanoic acid
-
Bos taurus