Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | lipopolysaccharide has no effect on expression in monocyte-derived dendritic cells | Homo sapiens | |
phorbol myristate acetate | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
into vector pET-28a(+) and expressed in Escherichia coli BL21-DE3 cells. BALB/c mice inoculated subcutaneously with recombinant CPVL. CHO cells transiently transfected with CPVL-EGFP expression vector | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
endoglycosidase H | lowers CPVL expression in monocyte-derived macrophages | Homo sapiens | |
additional information | O-glycosidase has no effect in monocyte-derived macrophages. CPVL in THP-1 and Jurkat cell lines are insensitive to treatment with a cocktail of O-glycosidase, N-glycosidase and endoglycosidase H | Homo sapiens | |
N-glycosidase | lowers CPVL expression in monocyte-derived macrophages | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
lamellipodium | - |
Homo sapiens | 30027 | - |
membrane | present in ruffles of macrophages, absent from outer plasma membrane | Homo sapiens | 16020 | - |
phagosome | CPVL present in early (5 min incubation) latex bead phagosomes, it is not retained in the mature, cathepsin D-positive phagolysosome (60 min incubation) | Candida albicans | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | - |
- |
- |
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
to more than 80% purity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | in primary macrophages, CPVL is glycosylated with high mannose residues | Homo sapiens | - |
monocyte | CPVL is up-regulated during the maturation of monocytes to macrophages. Expression in monocyte-derived dendritic cells | Homo sapiens | - |
additional information | present in Jurkat T-cell line, is not expressed by monocyte depleted peripheral blood mononuclear cells | Homo sapiens | - |
THP-1 cell | expressed in phorbol myristate acetate-stimulated cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | CPVL colocalizes with both macrophage-inhibitory protein-1alpha and tumour necrosis factor-alpha | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carboxypeptidase vitellogenic-like | - |
Homo sapiens |
CPVL | - |
Homo sapiens |
CPVL | - |
Candida albicans |
vitellogenic-like carboxypeptidase | - |
Candida albicans |