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Literature summary for 3.4.17.1 extracted from

  • Schneider, L.A.; Schlenner, S.M.; Feyerabend, T.B.; Wunderlin, M.; Rodewald, H.R.
    Molecular mechanism of mast cell mediated innate defense against endothelin and snake venom sarafotoxin (2007), J. Exp. Med., 204, 2629-2639.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.17.1

Application

Application Comment Organism
medicine mc-CPA is an essential effector molecule providing a very rapid and life-saving response of toxin neutralization in vivo Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
a pBSK-based vector construct is used for gene targeting Mus musculus

Protein Variants

Protein Variants Comment Organism
E378A Glu378 is crucial for ligand binding and hydrolysis of substrate peptide bond Mus musculus
Y356L Tyr356 is crucial for ligand binding and hydrolysis of substrate peptide bond Mus musculus
Y356L/E378A mutant expresses about 80% of the amount of Mc-cpa compared to the wild type enzyme, the mutant enzyme lacks activity Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
secretory granule
-
 Mus musculus 30141
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
 determined by SDS-PAGE and Western blotting Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mast cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
endothelin + H2O removal of the C-terminal tryptophan Mus musculus ?
-
 ?
N-[4-methoxyphenylazoformyl]-Phe-OH + H2O
-
 Mus musculus ?
-
 ?
N-[4-methoxyphenylazoformyl]-Phe-OH + H2O assay substrate Mus musculus ?
-
 ?
sarafotoxin + H2O removal of the C-terminal tryptophan Mus musculus ?
-
 ?
sarafotoxin 6b + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
carboxypeptidase a
-
 Mus musculus
CPA3
-
 Mus musculus
mast cell carboxypeptidase A
-
 Mus musculus
MC-CPA
-
 Mus musculus
MC-CPA mast cell carboxypeptidase A Mus musculus