Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.16.4 extracted from

  • Zervosen, A.; Lu, W.P.; Chen, Z.; White, R.E.; Demuth Jr., T.P.; Fr่re, J.M.
    Interactions between penicillin-binding proteins (PBPs) and two novel classes of PBP inhibitors, arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones (2004), Antimicrob. Agents Chemother., 48, 961-969.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.16.4

Inhibitors

Inhibitors Comment Organism Structure
arylakylidene imino-thiazolidin-4-ones 10 86% inhibition Escherichia coli
arylakylidene imino-thiazolidin-4-ones 11 82% inhibition Escherichia coli
arylakylidene imino-thiazolidin-4-ones 12 64% inhibition Escherichia coli
arylakylidene imino-thiazolidin-4-ones 13 83% inhibition Escherichia coli
arylakylidene imino-thiazolidin-4-ones 16 100% inhibition Escherichia coli
arylakylidene imino-thiazolidin-4-ones 17 100% inhibition Escherichia coli
arylakylidene imino-thiazolidin-4-ones 18 96% inhibition Escherichia coli
arylakylidene imino-thiazolidin-4-ones 19 84% inhibition Escherichia coli
arylakylidene imino-thiazolidin-4-ones 5 89% inhibition Escherichia coli
arylakylidene imino-thiazolidin-4-ones 6 92% inhibition Escherichia coli
arylakylidene imino-thiazolidin-4-ones 8 99% inhibition Escherichia coli
arylakylidene imino-thiazolidin-4-ones 9 85% inhibition Escherichia coli
arylalkylidene rhodanine derivative 1 88% inhibition Escherichia coli
arylalkylidene rhodanine derivative 2 95% inhibition Actinomadura sp.
arylalkylidene rhodanine derivative 2 94% inhibition Escherichia coli
arylalkylidene rhodanine derivative 2 75% inhibition Streptomyces sp. R61
arylalkylidene rhodanine derivative 3 83% inhibition Escherichia coli
arylalkylidene rhodanine derivative 4 95% inhibition Escherichia coli
additional information no significant inhibition by arylalkylidene rhodanine derivative 1 and 3 respectively and arylakylidene imino-thiazolidin-4-ones 6, 8, 13, 16, 17 and 19 respectively Actinomadura sp.
additional information no significant inhibition by arylakylidene imino-thiazolidin-4-ones 7, 14 and 15 respectively Escherichia coli
additional information no significant inhibition by arylalkylidene rhodanine derivative 1, 3 and 4 respectively and arylakylidene imino-thiazolidin-4-ones 5 to 19 Streptomyces sp. R61
penicillin G 100% inhibition Actinomadura sp.
penicillin G 100% inhibition Escherichia coli
penicillin G 100% inhibition Streptomyces sp. R61

Organism

Organism UniProt Comment Textmining
Actinomadura sp.
-
-
-
Escherichia coli
-
-
-
Streptomyces sp. R61
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Nalpha,Nepsilon-diacetyl-L-lysyl-D-alanyl-D-alanine + H2O
-
 Actinomadura sp. D-alanine + Nalpha,Nepsilon-diacetyl-L-lysyl-D-alanine
-
 ?
Nalpha,Nepsilon-diacetyl-L-lysyl-D-alanyl-D-alanine + H2O
-
 Streptomyces sp. R61 D-alanine + Nalpha,Nepsilon-diacetyl-L-lysyl-D-alanine
-
 ?
S2d thiolester
-
 Escherichia coli ?
-
 ?

Synonyms

Synonyms Comment Organism
DD-Carboxypeptidase
-
 Escherichia coli
DD-peptidase
-
 Actinomadura sp.
DD-peptidase
-
 Streptomyces sp. R61
PBP5
-
 Escherichia coli