Cloned (Comment) | Organism |
---|---|
cDNA cloned in pMT/BIP/V5-HIS-C, transfected into Schneider insect cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
angiotensin II | IC50: 3 mM, inhibits hydrolysis of Gly-Pro-4-nitroanilide | Homo sapiens | |
anti-PRCP | - |
Homo sapiens | |
benzyloxycarbonyl-Pro-Pro-aldehyde-dimethyl acetal | - |
Homo sapiens | |
benzyloxycarbonyl-Pro-prolinal | IC50: 0.5 mM, inhibits hydrolysis of H-Gly-Pro-4-nitroanilide | Homo sapiens | |
bradykinin | - |
Homo sapiens | |
corn trypsin inhibitor | binds to prekallikrein to prevent activation, but does not directly inhibit the active site of either enzyme | Homo sapiens | |
diisopropyl fluorophosphonate | IC50: 50 nM | Homo sapiens | |
leupeptin | IC50: 0.8 mM, inhibits hydrolysis of Gly-Pro-4-nitroanilide | Homo sapiens | |
additional information | no inhibition by 1 mM EDTA, bradykinin 1-5 or angiotensin 1-7 | Homo sapiens | |
phenylmethylsulfonyl fluoride | IC50: 0.6 mM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000017 | - |
prekallikrein | - |
Homo sapiens | |
2.4 | - |
Ala-Pro-4-nitroanilide | pH 5.5, 37°C | Homo sapiens | |
4 | - |
Gly-Pro-4-nitroanilide | pH 5.5, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | optimal activity at 0.01 mM | Homo sapiens | |
Mg2+ | optimal activity at 1 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
umbilical vein endothelial cell line | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ala-Pro-4-nitroanilide + H2O | - |
Homo sapiens | Ala-Pro + 4-nitroaniline | - |
? | |
Gly-Pro-4-nitroanilide + H2O | - |
Homo sapiens | Gly-Pro + 4-nitroaniline | - |
? | |
prekallikrein + H2O | - |
Homo sapiens | additional information | production of a 51000 Da heavy chain and 2 faint light chains of 39000 Da and 36000 Da | ? |
Synonyms | Comment | Organism |
---|---|---|
PRCP | - |
Homo sapiens |
serine protease prolylcarboxypeptidase | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.1 | - |
- |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00005 | - |
IC50: 50 nM | Homo sapiens | diisopropyl fluorophosphonate | |
0.5 | - |
IC50: 0.5 mM, inhibits hydrolysis of H-Gly-Pro-4-nitroanilide | Homo sapiens | benzyloxycarbonyl-Pro-prolinal | |
0.6 | - |
IC50: 0.6 mM | Homo sapiens | phenylmethylsulfonyl fluoride | |
0.8 | - |
IC50: 0.8 mM, inhibits hydrolysis of Gly-Pro-4-nitroanilide | Homo sapiens | leupeptin | |
3 | - |
IC50: 3 mM, inhibits hydrolysis of Gly-Pro-4-nitroanilide | Homo sapiens | angiotensin II |