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Literature summary for 3.4.15.4 extracted from
- Atrial tissue contains a metallo dipeptidyl carboxyhydrolase not present in ventricular tissue: partial purification and characterization (1984), Arch. Biochem. Biophys., 233, 667-675.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Bos taurus |  |
| 2-D-Methylsuccinyl-L-Pro | - |
Bos taurus | |
| 3-Mercaptopropanoyl-L-Pro | - |
Bos taurus | |
| bradykinin potentiating factor | - |
Bos taurus | |
| D-2-Methyl-3-mercaptopropanoyl-L-Pro | i.e. captopril | Bos taurus | |
| DTT | - |
Bos taurus | |
| EDTA | - |
Bos taurus | |
| mercaptoethanol | - |
Bos taurus | |
| additional information | marked substrate inhibition with benzoyl-Gly-His-Leu, but little or no substrate inhibition with benzoyl-Gly-His-Gly; the enzyme is 5500 times less sensitive to D-Cys-L-Pro, the very potent inhibitor of angiotensin I-converting enzyme (EC 3.4.15.1) | Bos taurus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.8 | - |
benzoyl-Gly-His-Leu | - |
Bos taurus | |
| 2.4 | - |
benzoyl-Gly-His-Gly | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Bos taurus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | in contrast to peptidyl-dipeptidase A (EC 3.4.15.1) it displays no dependence on Cl- | Bos taurus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 240000 | - |
bovine, sucrose density gradient sedimentation, gel filtration | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| atrium | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Atriopeptin II + H2O | - |
Bos taurus | Atriopeptin I + ? | - |
? | |
| benzoyl-Gly-His-Gly + H2O | - |
Bos taurus | benzoyl-Gly + His-Gly | - |
? | |
| benzoyl-Gly-His-Leu + H2O | - |
Bos taurus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.3 | - |
- |
Bos taurus |
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Release 2023.1 (January 2023)
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