Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.15.1 extracted from

  • Kolesnyk, I.; Struijk, D.G.; Dekker, F.W.; Krediet, R.T.
    Effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in patients with chronic kidney disease (2010), Neth. J. Med., 68, 15-23.
    View publication on PubMed
Search for more literature for 3.4.15.1

Application

Application Comment Organism
medicine enzyme inhibitors are useful in treatment of hypertension and heart failure, as well as for peritoneal dialysis patients, because inhibit the local tissue renin-angiotensin system, which results in less development of peritoneal fibrosis and a longer life for the peritoneal membrane, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
captopril the ACE inhibitor shows best renoprotective effect in patients with renal disease Homo sapiens
additional information antiproteinuric and renoprotective effects of ACE inhibitors, ACEi, overview Homo sapiens
ramipril the ACE inhibitor is associated with a major reduction of proteinuria, slower GFR decline and risk of doubling serum creatinine or progression to end-stage renal disease in patients with nondiabetic kidney disease Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
ACE
-
 Homo sapiens
angiotensin-converting enzyme
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction ACE is involved in risk of GFR decrease, doubling of serum creatinine or progression to ESRD in renal disease Homo sapiens
physiological function enzyme inhibitors are useful in treatment of hypertension and heart failure, as well as for peritoneal dialysis patients, because inhibit the local tissue renin-angiotensin system, which results in less development of peritoneal fibrosis and a longer life for the peritoneal membrane, overview Homo sapiens