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Literature summary for 3.4.15.1 extracted from
- Effect of combined angiotensin-converting enzyme and aldosterone inhibition on plasma plasminogen activator inhibitor type 1 levels in chronic hypertensive patients (2010), Nephrology, 15, 211-215.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| fosinopril | causes a significant decrease in plasminogen activator inhibitor 1, PAI-1, levels, probably by aldosterone escape | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensin I + H2O | Homo sapiens | - |
angiotensin II + His-Leu | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensin I + H2O | - |
Homo sapiens | angiotensin II + His-Leu | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACE | - |
Homo sapiens |
| angiotensin-converting enzyme | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | ACE is responsible for degradation of bradykinin which is the most potent stimulus for tissue plasminogen activator secretion. The reaction product from angiotensin I cleavage, angiotensin II, has an important role on fibrinolytic balance causing release of plasminogen activator inhibitor 1 and consequently inhibits fibrinolysis | Homo sapiens |
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Release 2023.1 (January 2023)
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