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Literature summary for 3.4.15.1 extracted from

  • Hoover, T.; Lippmann, M.; Grouzmann, E.; Marceau, F.; Herscu, P.
    Angiotensin converting enzyme inhibitor induced angio-oedema: a review of the pathophysiology and risk factors (2010), Clin. Exp. Allergy, 40, 50-61.
    View publication on PubMed
Search for more literature for 3.4.15.1

Inhibitors

Inhibitors Comment Organism Structure
angiotensin converting enzyme inhibitor ACE-I, inhibition is impacting both the renin-angiotensin cascade and the degradation metabolism of bradykinin, inhibition mechanism, overview. ACE-I is used as therapeutic agent in congestive heart failure, diabetic nephropathy, hypertension, and coronary artery disease. ACE-I medications can induce chronic cough, hypotension, hyperkalemia, bone marrow depression, angioedema, and rarely, hepatic failure. Angioedema involves a subcutaneous swelling reaction that evolves over several hours and is not associated with itching or pain, pathomechanism, detailed overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Homo sapiens
-
 angiotensin II + His-Leu
-
 ?
bradykinin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Homo sapiens angiotensin II + His-Leu
-
 ?
bradykinin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ACE
-
 Homo sapiens
angiotensin converting enzyme
-
 Homo sapiens
kininase II
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism ACE is involved in the renin-angiotensin-aldosterone system, overview Homo sapiens