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Literature summary for 3.4.15.1 extracted from

  • Bas, M.; Hoffmann, T.K.; Tiemann, B.; Dao, V.T.; Bantis, C.; Balz, V.; Schultz-Coulon, H.J.; Stark, T.; Schuler, P.; Greve, J.; Ivens, K.; Bier, H.; Kojda, G.
    Potential genetic risk factors in angiotensin-converting enzyme-inhibitor-induced angio-oedema (2010), Br. J. Clin. Pharmacol., 69, 179-186.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.15.1

Cloned(Commentary)

Cloned (Comment) Organism
ACE insertion/deletion genotyping Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information ACE insertion/deletion and bradykinin B2 receptor polymorphisms are not involved in the development of ACEi-induced angio-oedema, ACE insertion/deletion polymorphism identification and analysis, overview Homo sapiens
additional information polymorphism of ACE insertion/deletion, e.g. cC181T, and the bradykinin B2 receptor polymorphisms are not involved in the development of ACEi-induced angioedema, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
angiotensin-converting enzyme inhibitor ACEi, induces angioedema, a non-allergic bradykinin-induced drug side-effect and clinical life-threatening problem, overview. ACE insertion/deletion and bradykinin B2 receptor polymorphisms are not involved in the development of ACEi-induced angio-oedema Homo sapiens
additional information ACE inhibitors can induce angioedema, overview; ACE-inhibitors in vivo act in a competitive manner and their activity is dependent on their plasma concentration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
bradykinin + H2O Homo sapiens degradation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood serum
-
 Homo sapiens
-
serum
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 ACE activities in serum from angioedema patients, overview Homo sapiens
additional information
-
 ACE I/D polymorphism in relation to ACE serum activity, serum activity in U/l, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bradykinin + H2O
-
 Homo sapiens ?
-
 ?
bradykinin + H2O degradation Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ACE
-
 Homo sapiens
angiotensin-converting enzyme
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction ACE inhibitors can induce angioedema, overview. Polymorphism of ACE insertion/deletion and the bradykinin B2 receptor polymorphisms are not involved in the development of ACEi-induced angioedema, overview Homo sapiens