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Literature summary for 3.4.15.1 extracted from
- Angiotensin-converting enzyme as a potential target for treatment of Alzheimer's disease: inhibition or activation? (2008), Rev. Neurosci., 19, 203-212.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | angiotensin-converting enzyme is a potential target for treatment of Alzheimer's disease | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | zinc metallopeptidase | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid beta-protein 1-40 + H2O | Homo sapiens | ACE cleaves amyloid beta-protein 1-40 between Asp7 and Ser8 | amyloid beta-peptide(1-7) + amyloid beta-peptide(8-40) | - |
? | |
| amyloid beta-protein 1-42 + H2O | Homo sapiens | ACE cleaves amyloid beta-protein 1-42 at multiple sites | amyloid beta-peptide(1-40) + amyloid beta-peptide(41-42) | - |
? | |
| angiotensin I + H2O | Homo sapiens | - |
angiotensin II + L-His-L-Leu | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
| cerebrospinal fluid | - |
Homo sapiens | - |
| endothelial cell | - |
Homo sapiens | - |
| epithelial cell | - |
Homo sapiens | - |
| neuroepithelial cell | - |
Homo sapiens | - |
| serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid beta-protein 1-40 + H2O | ACE cleaves amyloid beta-protein 1-40 between Asp7 and Ser8 | Homo sapiens | amyloid beta-peptide(1-7) + amyloid beta-peptide(8-40) | - |
? | |
| amyloid beta-protein 1-42 + H2O | ACE cleaves amyloid beta-protein 1-42 at multiple sites | Homo sapiens | amyloid beta-peptide(1-40) + amyloid beta-peptide(41-42) | - |
? | |
| angiotensin I + H2O | - |
Homo sapiens | angiotensin II + L-His-L-Leu | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACE | - |
Homo sapiens |
| angiotensin-converting enzyme | - |
Homo sapiens |
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