Literature summary for 3.4.15.1 extracted from

Katayama, K.; Tomatsu, M.; Kawahara, S.; Yamauchi, K.; Fuchu, H.; Kodama, Y.; Kawamura, Y.; Muguruma, M.
Inhibitory profile of nonapeptide derived from porcine troponin C against angiotensin I-converting enzyme (2004), J. Agric. Food Chem., 52, 771-775.

Search for more literature for 3.4.15.1

Inhibitors

Inhibitors	Comment	Organism	Structure
Arg-Met-Leu	IC50: 1.019 mM, competitive inhibition	Bos taurus
Gly-Gln	IC50: 5.63 mM, competitive inhibition	Bos taurus
RMLGQ	IC50: 0.358 mM, competitive inhibition	Bos taurus
RMLGQTP	IC50: 0.503 mM, mixed-type inhibition	Bos taurus
RMLGQTPTK	IC50: 0.034 mM, noncompetitive inhibition	Bos taurus
Thr-Lys	IC50: 1.634 mM, mixed-type inhibition	Bos taurus
Thr-Pro	IC50: 2.071 mM, competitive inhibition	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
hippuryl-His-Leu + H2O	-	Bos taurus	hippuric acid + His-Leu	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0606	-	RMLGQTPTK	pH 8.5	Bos taurus
0.1004	-	Thr-Pro	pH 8.5	Bos taurus
0.1215	-	RMLGQTP	pH 8.5	Bos taurus
0.1672	-	RMLGQ	pH 8.5	Bos taurus
0.3176	-	Arg-Met-Leu	pH 8.5	Bos taurus
0.5547	-	Gly-Gln	pH 8.5	Bos taurus
0.6164	-	Thr-Lys	pH 8.5	Bos taurus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.034	-	IC50: 0.034 mM, noncompetitive inhibition	Bos taurus	RMLGQTPTK
0.358	-	IC50: 0.358 mM, competitive inhibition	Bos taurus	RMLGQ
0.503	-	IC50: 0.503 mM, mixed-type inhibition	Bos taurus	RMLGQTP
1.019	-	IC50: 1.019 mM, competitive inhibition	Bos taurus	Arg-Met-Leu
1.634	-	IC50: 1.634 mM, mixed-type inhibition	Bos taurus	Thr-Lys
2.071	-	IC50: 2.071 mM, competitive inhibition	Bos taurus	Thr-Pro
5.63	-	IC50: 5.63 mM, competitive inhibition	Bos taurus	Gly-Gln

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Release 2023.1 (January 2023)