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Literature summary for 3.4.14.9 extracted from

  • Tian, Y.; Sohar, I.; Taylor, J.W.; Lobel, P.
    Determination of the substrate specificity of tripeptidyl-peptidase I using combinatorial peptide libraries and development of improved fluorogenic substrates (2006), J. Biol. Chem., 281, 6559-6572.
    View publication on PubMed
Search for more literature for 3.4.14.9

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.028
-
 Ala-Nle-Leu-7-amido-4-carbamoylmethylcoumarin pH 4.5, 30°C Homo sapiens
0.03
-
 Ala-Nva-Nle-7-amido-4-carbamoylmethylcoumarin pH 4.5, 30°C Homo sapiens
0.037
-
 Ala-Nle-Nle-7-amido-4-carbamoylmethylcoumarin pH 4.5, 30°C Homo sapiens
0.054
-
 Arg-Pro-Phe-7-amido-4-carbamoylmethylcoumarin pH 4.5, 30°C Homo sapiens
0.188
-
 Ala-Ala-Phe-7-amido-4-methylcoumarin pH 4.5, 30°C Homo sapiens
0.233
-
 Ala-Ala-Phe-7-amido-4-carbamoylmethylcoumarin pH 4.5, 30°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-Ala-Phe-7-amido-4-carbamoylmethylcoumarin + H2O
-
 Homo sapiens Ala-Ala-Phe + 7-amino-4-carbamoylmethylcoumarin
-
 ?
Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Ala-Ala-Phe + 7-amino-4-methylcoumarin
-
 ?
Ala-Nle-Leu-7-amido-4-carbamoylmethylcoumarin + H2O
-
 Homo sapiens Ala-Nle-Leu + 7-amino-4-carbamoylmethylcoumarin
-
 ?
Ala-Nle-Nle-7-amido-4-carbamoylmethylcoumarin + H2O
-
 Homo sapiens Ala-Nle-Nle + 7-amino-4-carbamoylmethylcoumarin
-
 ?
Ala-Nva-Nle-7-amido-4-carbamoylmethylcoumarin + H2O
-
 Homo sapiens Ala-Nva-Nle + 7-amino-4-carbamoylmethylcoumarin
-
 ?
Arg-Pro-Phe-7-amido-4-carbamoylmethylcoumarin + H2O
-
 Homo sapiens Arg-Pro-Phe + 7-amino-4-carbamoylmethylcoumarin
-
 ?
additional information determination of the substrate specificity of tripeptidyl-peptidase I using combinatorial peptide libraries and development of improved fluorogenic substrates Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
TPP I
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.6
-
 Ala-Nle-Leu-7-amido-4-carbamoylmethylcoumarin pH 4.5, 30°C Homo sapiens
4.2
-
 Ala-Nle-Nle-7-amido-4-carbamoylmethylcoumarin pH 4.5, 30°C Homo sapiens
4.7
-
 Ala-Nva-Nle-7-amido-4-carbamoylmethylcoumarin pH 4.5, 30°C Homo sapiens
5.2
-
 Ala-Ala-Phe-7-amido-4-methylcoumarin pH 4.5, 30°C Homo sapiens
5.3
-
 Ala-Ala-Phe-7-amido-4-carbamoylmethylcoumarin pH 4.5, 30°C Homo sapiens
8.2
-
 Arg-Pro-Phe-7-amido-4-carbamoylmethylcoumarin pH 4.5, 30°C Homo sapiens