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Literature summary for 3.4.14.5 extracted from

  • Bar-Or, D.; Slone, D.S.; Mains, C.W.; Rael, L.T.
    Dipeptidyl peptidase IV activity in commercial solutions of human serum albumin (2013), Anal. Biochem., 441, 13-17.
    View publication on PubMed

Application

Application Comment Organism
analysis significant levels of enzyme activity are present in commercial human serum albumin. This activity is abolished using a specific DPP-IV inhibitor. Fully 70 to 80% DPP-IV activity remains at 60°C compared with the 37°C incubate. No DPP-IV activity is present in recombinant human serum albumin, suggesting that DPP-IV activity is present only in serum albumin produced using the Cohn fractionation process. DPP-IV activity contributes to the formation of aspartate-alanine diketopiperazine, a known immunomodulatory molecule from the N terminus of human albumin, could account for some of the clinical effects of commercial human serum albumin Homo sapiens
medicine significant levels of enzyme activity are present in commercial human serum albumin. This activity is abolished using a specific DPP-IV inhibitor. Fully 70 to 80% DPP-IV activity remains at 60°C compared with the 37°C incubate. No DPP-IV activity is present in recombinant human serum albumin, suggesting that DPP-IV activity is present only in serum albumin produced using the Cohn fractionation process. DPP-IV activity contributes to the formation of aspartate-alanine diketopiperazine, a known immunomodulatory molecule from the N terminus of human albumin, could account for some of the clinical effects of commercial human serum albumin Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation commercial solution of human serum albumin Homo sapiens
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