Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(S)-1-(2-(2-(2-oxo-3-(3,4,5-trimethoxyphenyl)imidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(S)-1-(2-(2-(2-oxo-3-p-tolylimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(S)-1-(2-(2-(2-oxo-3-phenylimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(S)-1-(2-(2-(3-(2-fluorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(S)-1-(2-(2-(3-(3,4-dimethoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(S)-1-(2-(2-(3-(3,5-dimethoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(S)-1-(2-(2-(3-(3-fluorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(S)-1-(2-(2-(3-(3-methoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(S)-1-(2-(2-(3-(4-chlorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(S)-1-(2-(2-(3-(4-fluorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(S)-1-(2-(2-(3-(4-methoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(S)-1-(2-(2-(3-butyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(S)-1-(2-(2-(3-cyclohexyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(S)-1-(2-(2-(3-isopropyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
(S)-1-(2-(2-(3-tert-butyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
alogliptin | SYR-322 | Homo sapiens | |
saxagliptin | BMS477118 | Homo sapiens | |
sitagliptin | MK-0431 | Homo sapiens | |
vildagliptin | LAF-237 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glucagon-like peptide 1 + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glucagon-like peptide 1 + H2O | - |
Homo sapiens | ? | - |
? | |
Gly-L-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Gly-L-Pro + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CD26 | - |
Homo sapiens |
dipeptidyl peptidase IV | - |
Homo sapiens |
DPP-IV | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000002 | - |
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C | Homo sapiens | (S)-1-(2-(2-(3-(3,4-dimethoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | |
0.0000166 | - |
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C | Homo sapiens | vildagliptin | |
0.0000204 | - |
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C | Homo sapiens | (S)-1-(2-(2-(3-(3,5-dimethoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | |
0.0000258 | - |
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C | Homo sapiens | (S)-1-(2-(2-(3-(4-chlorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | |
0.0000293 | - |
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C | Homo sapiens | (S)-1-(2-(2-(2-oxo-3-p-tolylimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | |
0.0000348 | - |
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C | Homo sapiens | (S)-1-(2-(2-(2-oxo-3-phenylimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | |
0.0000445 | - |
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C | Homo sapiens | (S)-1-(2-(2-(3-(4-fluorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | |
0.0000478 | - |
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C | Homo sapiens | (S)-1-(2-(2-(3-isopropyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | |
0.0000535 | - |
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C | Homo sapiens | (S)-1-(2-(2-(3-butyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | |
0.0000601 | - |
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C | Homo sapiens | (S)-1-(2-(2-(3-(3-fluorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | |
0.0000651 | - |
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C | Homo sapiens | (S)-1-(2-(2-(3-(3-methoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | |
0.0000681 | - |
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C | Homo sapiens | (S)-1-(2-(2-(3-tert-butyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | |
0.0000686 | - |
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C | Homo sapiens | (S)-1-(2-(2-(3-cyclohexyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | |
0.0000824 | - |
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C | Homo sapiens | (S)-1-(2-(2-(3-(4-methoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | |
0.0001336 | - |
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C | Homo sapiens | (S)-1-(2-(2-(3-(2-fluorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile | |
0.0001656 | - |
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C | Homo sapiens | (S)-1-(2-(2-(2-oxo-3-(3,4,5-trimethoxyphenyl)imidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile |