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Literature summary for 3.4.14.5 extracted from

  • Boehringer, M.; Fischer, H.; Hennig, M.; Hunziker, D.; Huwyler, J.; Kuhn, B.; Loeffler, B.M.; Luebbers, T.; Mattei, P.; Narquizian, R.; Sebokova, E.; Sprecher, U.; Wessel, H.P.
    Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors (2010), Bioorg. Med. Chem. Lett., 20, 1106-1108.
    View publication on PubMed
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
(2S,3S,11bS)-3-(2,5-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2S,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2S,3S,11bS)-3-(3-cyclopropylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2S,3S,11bS)-3-(3-ethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2S,3S,11bS)-3-butyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2S,3S,11bS)-3-[3-(fluoromethyl)phenyl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2S,3S,11bS)-3-[4-(fluoromethyl)pyridin-2-yl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2S,3S,11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2S,3S,11bS)-9,10-dimethoxy-3-(4-methylpyridin-2-yl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2S,3S,11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
(2S,3S,11bS)-9,10-dimethoxy-3-[3-(propan-2-yl)phenyl]-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
 Homo sapiens
5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-phenylpyrimidin-4-amine
-
 Homo sapiens
5-(aminomethyl)-6-(4-chlorophenyl)-2-phenylpyrimidin-4-amine
-
 Homo sapiens
saxagliptin
-
 Homo sapiens
sitagliptin
-
 Homo sapiens
vildagliptin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucagon-like peptide 1 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glucagon-like peptide 1 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase IV
-
 Homo sapiens
DPP-IV
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000005
-
-
 Homo sapiens (2S,3S,11bS)-3-[3-(fluoromethyl)phenyl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.0000012
-
-
 Homo sapiens (2S,3S,11bS)-3-[4-(fluoromethyl)pyridin-2-yl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.0000017
-
-
 Homo sapiens (2S,3S,11bS)-3-(2,5-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.0000042
-
-
 Homo sapiens (2S,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.0000046
-
-
 Homo sapiens (2S,3S,11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.000019
-
-
 Homo sapiens (2S,3S,11bS)-9,10-dimethoxy-3-(4-methylpyridin-2-yl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.000038
-
-
 Homo sapiens (2S,3S,11bS)-3-(3-cyclopropylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.000061
-
-
 Homo sapiens (2S,3S,11bS)-3-(3-ethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.0002
-
-
 Homo sapiens (2S,3S,11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.0055
-
-
 Homo sapiens (2S,3S,11bS)-9,10-dimethoxy-3-[3-(propan-2-yl)phenyl]-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine