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Literature summary for 3.4.14.5 extracted from

  • Tahara, A.; Matsuyama-Yokono, A.; Nakano, R.; Someya, Y.; Hayakawa, M.; Shibasaki, M.
    Evaluation of the antidiabetic effects of dipeptidyl peptidase-IV inhibitor ASP8497 in streptozotocin-nicotinamide-induced mildly diabetic mice (2009), Pharmacology, 83, 177-187.
    View publication on PubMed
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
ASP8497 i.e. (2S,4S)-4-fluoro-1-([[4-methyl-1-(methylsulfonyl)-piperidin-4-yl]amino]acetyl)pyrrolidine-2-carbonitrile monofumarate, potent and long-acting inhibitor of plasma DPP-IV activity, inhibitory activity lasts up to 24 h when administered at 5 mg/kg twice a day or 10 mg/kg once a day Mus musculus
saxagliptin BMS-477178, (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]-hexane-3-carbonitrile hydrochloride Mus musculus
sitagliptin MK-0431, (2 R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo-[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate Mus musculus
vildagliptin LAF237, 1-[[(3-hydroxy-1-adamantyl)-amino]acetyl]-2-cyano-(S)-pyrrolidine Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucagon-like peptide 1 + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glucagon-like peptide 1 + H2O
-
 Mus musculus ?
-
 ?
Gly-L-Pro-7-amido-4-methylcoumarin + H2O
-
 Mus musculus Gly-L-Pro + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase-IV
-
 Mus musculus
DPP-IV
-
 Mus musculus