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Literature summary for 3.4.14.5 extracted from
- Combination of the dipeptidyl peptidase IV inhibitor LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] with the angiotensin II type 1 receptor antagonist valsartan [N-(1-oxopentyl)-N-[[2-(1H-tetrazol-5-yl)-[1,1-biphenyl]-4-yl]methyl]-L-valine ] enhances pancreatic islet morphology and function in a mouse model of type 2 diabetes (2008), J. Pharmacol. Exp. Ther., 327, 683-691.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| LAF237 | i.e. (S)-1-[(3-hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine | Mus musculus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glucagon-like peptide 1 + H2O | Mus musculus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreatic beta cell | - |
Mus musculus | - |
| pancreatic islet | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glucagon-like peptide 1 + H2O | - |
Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dipeptidyl peptidase IV | - |
Mus musculus |
| DPP-IV | - |
Mus musculus |
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