Literature summary for 3.4.14.5 extracted from

Garcia-Soria, G.; Gonzalez-Galvez, G.; Argoud, G.M.; Gerstman, M.; Littlejohn, T.W.; Schwartz, S.L.; OFarrell, A.M.; Li, X.; Cherrington, J.M.; Bennett, C.; Guler, H.P.
The dipeptidyl peptidase-4 inhibitor PHX1149 improves blood glucose control in patients with type 2 diabetes mellitus (2008), Diabetes Obes. Metab., 10, 293-300.

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Inhibitors

Inhibitors	Comment	Organism	Structure
PHX1149	selective DPP4 inhibitor, DPP4 inhibition on day 28 is 53%, 73% and 78% at 24 h after treatment with 100, 200 and 400 mg PHX1149, respectively	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Gly-L-Pro-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	Gly-L-Pro + 7-amino-4-methylcoumarin	-	?

Synonyms

Synonyms	Comment	Organism
dipeptidyl peptidase-4	-	Homo sapiens
DPP4	-	Homo sapiens

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Release 2023.1 (January 2023)