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Literature summary for 3.4.14.5 extracted from

  • Clairmont, K.B.; Buckholz, T.M.; Pellegrino, C.M.; Buxton, J.M.; Barucci, N.; Bell, A.; Ha, S.; Li, F.; Claus, T.H.; Salhanick, A.I.; Lumb, K.J.
    Engineering of a VPAC2 receptor peptide agonist to impart dipeptidyl peptidase IV stability and enhance in vivo glucose disposal (2006), J. Med. Chem., 49, 7545-7548.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
VPAC2P-PEG + H2O VPAC2P-PEG is a VPAC2 receptor agonist peptide that acts as a glucose-dependent insulin secretagogue. Proteolysis by DPPIV may contribute to the in vivo clearance of VPAC2P-PEG. The N-terminus of VPAC2P-PEG is modified by N-terminal acetylation to impart DPPIV resistance. The acetylated peptide, Ac-VPAC2P-PEG, is a selective and potent VPAC2 agonist, resistant to DPPIV proteolysis Homo sapiens ?
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Synonyms

Synonyms Comment Organism
DPPIV
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Homo sapiens