Literature summary for 3.4.14.5 extracted from

Thielitz, A.; Reinhold, D.; Vetter, R.; Bank, U.; Helmuth, M.; Hartig, R.; Wrenger, S.; Wiswedel, I.; Lendeckel, U.; Kaehne, T.; Neubert, K.; Faust, J.; Zouboulis, C.C.; Ansorge, S.; Gollnick, H.
Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation (2007), J. Invest. Dermatol., 127, 1042-1051.

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Application

Application	Comment	Organism
medicine	functional role of dipeptidyl peptidase IV and aminopeptidase N in the sebaceous gland apparatus and for their inhibitors, used alone or in combination, as substances possibly affecting acne pathogenesis in a therapeutic manner	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Lys[Z(NO2)]-pyrrolidide	the dipeptidyl peptidase IV inhibitor suppresses proliferation, enhances terminal differentiation and slightly decreases total neutral lipid production in sebocytes	Homo sapiens
Lys[Z(NO2)]-thiazolidide	the dipeptidyl peptidase IV inhibitor suppresses proliferation, enhances terminal differentiation and slightly decreases total neutral lipid production in sebocytes	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
sebocyte	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
dipeptidyl peptidase IV	-	Homo sapiens
DP IV	-	Homo sapiens

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Release 2023.1 (January 2023)