Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.14.5 extracted from

  • Simpkins, L.M.; Bolton, S.; Pi, Z.; Sutton, J.C.; Kwon, C.; Zhao, G.; Magnin, D.R.; Augeri, D.J.; Gungor, T.; Rotella, D.P.; Sun, Z.; Liu, Y.; Slusarchyk, W.S.; Marcinkeviciene, J.; Robertson, J.G.; Wang, A.; Robl, J.A.; Atwal, K.S.; Zahler, R.L.; Parker, R.A.; Kirby, M.S.; Hamann, L.G.
    Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors (2007), Bioorg. Med. Chem. Lett., 17, 6476-6480.
    View publication on PubMed
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
(1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
-
 Homo sapiens
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-1-oxo-3-phenylpropan-2-amine
-
 Homo sapiens
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-1-oxohexan-2-amine
-
 Homo sapiens
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3,3-dimethyl-1-oxobutan-2-amine
-
 Homo sapiens
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-(4-chlorophenyl)-1-oxopropan-2-amine
-
 Homo sapiens
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-methyl-1-oxobutan-2-amine
-
 Homo sapiens
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-4-methyl-3-(1-methylethyl)-1-oxopentan-2-amine
-
 Homo sapiens
(2S,3R)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-methyl-1-oxopentan-2-amine
-
 Homo sapiens
(2S,3S)-2-amino-1-((1S,5S)-2-azabicyclo[3.1.0]hexan-2-yl)-3-methylpentan-1-one
-
 Homo sapiens
1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-4,4-dimethyl-1-oxopentan-2-amine
-
 Homo sapiens
3-(1-amino-2-oxo-2-pyrrolidin-1-ylethyl)tricyclo[3.3.1.13,7]decan-1-ol
-
 Homo sapiens
3-[1-amino-2-(2H-isoindol-2-yl)-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol
-
 Homo sapiens
3-[1-amino-2-(4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol
-
 Homo sapiens
3-[1-amino-2-oxo-2-(1,3-thiazolidin-3-yl)ethyl]tricyclo[3.3.1.13,7]decan-1-ol
-
 Homo sapiens
3-[1-amino-2-[(1R,5S)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol
-
 Homo sapiens
3-[1-amino-2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]-5,7-dimethyltricyclo[3.3.1.13,7]decan-1-ol
-
 Homo sapiens
3-[1-amino-2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol
-
 Homo sapiens
4-[(2S)-2-amino-3-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-oxopropyl]phenol
-
 Homo sapiens
5-([2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]amino)tricyclo[3.3.1.13,7]decane-1,3-diol
-
 Homo sapiens
5-[1-amino-2-(3-azabicyclo[3.1.0]hex-3-yl)-2-oxoethyl]tricyclo[3.3.1.13,7]decane-1,3-diol
-
 Homo sapiens
5-[1-amino-2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]tricyclo[3.3.1.13,7]decane-1,3-diol
-
 Homo sapiens
saxagliptin
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000006
-
 saxagliptin
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000029
-
-
 Homo sapiens 3-[1-amino-2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]-5,7-dimethyltricyclo[3.3.1.13,7]decan-1-ol
0.00001
-
-
 Homo sapiens 3-[1-amino-2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol
0.000014
-
-
 Homo sapiens 5-[1-amino-2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]tricyclo[3.3.1.13,7]decane-1,3-diol
0.000028
-
-
 Homo sapiens 3-[1-amino-2-oxo-2-(1,3-thiazolidin-3-yl)ethyl]tricyclo[3.3.1.13,7]decan-1-ol
0.000049
-
-
 Homo sapiens 3-(1-amino-2-oxo-2-pyrrolidin-1-ylethyl)tricyclo[3.3.1.13,7]decan-1-ol
0.000112
-
-
 Homo sapiens (2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-4-methyl-3-(1-methylethyl)-1-oxopentan-2-amine
0.00027
-
-
 Homo sapiens 5-[1-amino-2-(3-azabicyclo[3.1.0]hex-3-yl)-2-oxoethyl]tricyclo[3.3.1.13,7]decane-1,3-diol
0.000356
-
-
 Homo sapiens (2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3,3-dimethyl-1-oxobutan-2-amine
0.00053
-
-
 Homo sapiens (2S,3S)-2-amino-1-((1S,5S)-2-azabicyclo[3.1.0]hexan-2-yl)-3-methylpentan-1-one
0.000607
-
-
 Homo sapiens 3-[1-amino-2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]-5,7-dimethyltricyclo[3.3.1.13,7]decan-1-ol
0.000731
-
-
 Homo sapiens (2S,3R)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-methyl-1-oxopentan-2-amine
0.000877
-
-
 Homo sapiens (2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-(4-chlorophenyl)-1-oxopropan-2-amine
0.00101
-
-
 Homo sapiens 1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-4,4-dimethyl-1-oxopentan-2-amine
0.001065
-
-
 Homo sapiens (2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-methyl-1-oxobutan-2-amine
0.00142
-
-
 Homo sapiens 3-[1-amino-2-(2H-isoindol-2-yl)-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol
0.001944
-
-
 Homo sapiens 3-[1-amino-2-[(1R,5S)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol
0.003007
-
-
 Homo sapiens 4-[(2S)-2-amino-3-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-oxopropyl]phenol
0.003081
-
-
 Homo sapiens 5-([2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]amino)tricyclo[3.3.1.13,7]decane-1,3-diol
0.003257
-
-
 Homo sapiens (2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-1-oxohexan-2-amine
0.003311
-
-
 Homo sapiens 3-[1-amino-2-(4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol
0.003653
-
-
 Homo sapiens (2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-1-oxo-3-phenylpropan-2-amine