Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.14.5 extracted from

  • Ryo, M.
    Some properties of bacterial dipeptidyl peptidase IV (2001), Int. Congr. Ser., 1218, 395-399.
No PubMed abstract available
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
diisopropylfluorophosphate marked inhibition at 1 mM Streptococcus salivarius
Gly-Pro competitive inhibition Streptococcus salivarius
additional information no inhibition by sulfhydryl-blocking agents and metal chelators, no inhibition by Pro, Pro-Gly, and Pro-Gly-Gly Streptococcus salivarius

Metals/Ions

Metals/Ions Comment Organism Structure
additional information not affected by various cations Streptococcus salivarius

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
47000
-
 2 * 47000, SDS-PAGE Streptococcus salivarius
109000
-
 gel filtration Streptococcus salivarius

Organism

Organism UniProt Comment Textmining
Streptococcus salivarius
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein the desialylated enzyme is attacked by proteases Streptococcus salivarius

Purification (Commentary)

Purification (Comment) Organism
114fold Streptococcus salivarius

Reaction

Reaction Comment Organism Reaction ID
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline specific for hydrolysis of peptide bond on the carboxylic side of proline residues which are penultimate from the amino terminus Streptococcus salivarius
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gly-Pro-4-nitroanilide + H2O
-
 Streptococcus salivarius Gly-Pro + 4-nitroaniline
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 47000, SDS-PAGE Streptococcus salivarius

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase IV
-
 Streptococcus salivarius
DPPIV
-
 Streptococcus salivarius

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.7
-
 Gly-NaOH buffer Streptococcus salivarius

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
5.3
-
 Gly-Pro versus Gly-Pro-4-nitroanilide Streptococcus salivarius

pI Value

Organism Comment pI Value Maximum pI Value
Streptococcus salivarius
-
-
 4.2