Inhibitors | Comment | Organism | Structure |
---|---|---|---|
human HIV-1 Gly3-Tat(1-9) peptide | amino acid sequence MDGVDPNIE, parabolic mixed type inhibition | Homo sapiens | |
human HIV-1 Ile3-Tat(1-9) peptide | amino acid sequence MDIVDPNIE, parabolic mixed type inhibition | Homo sapiens | |
human HIV-1 Lys2-Tat(1-9) peptide | amino acid sequence MKPVDPNIE, linear mixed type inhibition | Homo sapiens | |
human HIV-1 Tat protein | viral protein, inhibits the enzyme activity and cell proliferation | Homo sapiens | |
human HIV-1 Tat(1-9) peptide | amino acid sequence MDPVDPNIE, N-terminal peptide of the viral Tat protein, inhibits the enzyme activity and cell proliferation, parabolic mixed type inhibition | Homo sapiens | |
human HIV-1 Trp1-Tat(1-9) peptide | amino acid sequence WDPVDPNIE, parabolic mixed type inhibition | Homo sapiens | |
human HIV-1 Trp2-Tat(1-9) peptide | amino acid sequence MWPVDPNIE, linear mixed type inhibition | Homo sapiens | |
interleukin-2 peptide Met-IL-2(1-12) | amino acid sequence MAPTSSSTKKTQL, linear mixed type inhibition | Homo sapiens | |
interleukin-2 peptide Met-TRp1-IL-2(1-8) | amino acid sequence MWPTSSSTK, competitive inhibition | Homo sapiens | |
Met-Trp-Pro | competitive inhibition | Homo sapiens | |
Met-Trp-Val | linear-mixed type inhibition | Homo sapiens | |
Met-Trp1-G-CSF(1-8) peptide | amino acid sequence MWPLGPASS, G-CSF is the granulocyte colony stimulating factor, linear mixed type inhibition | Homo sapiens | |
Pro-Pro-[OPh-4 Cl]2 | irreversible | Homo sapiens | |
thromboxane A2 receptor peptide TXA2-R(1-9) | N-terminal MWP sequence motif MWPNGSSLG, potent competitive inhibitor, possibly functionally involved in antigen presentation by inhibiting T-cell expressed enzyme | Homo sapiens | |
Trp2,Ile3-Tat(1-9) peptide | amino acid sequence MWIVDPNIE, competitive inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | enzyme plays an important role in the activation and proliferation of lymphocytes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline | reaction mechanism | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lymphocyte | - |
Homo sapiens | - |
T-cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ala-Pro-4-nitroanilide + H2O | - |
Homo sapiens | Ala-Pro + 4-nitroaniline | - |
? | |
additional information | enzyme plays an important role in the activation and proliferation of lymphocytes | Homo sapiens | ? | - |
? | |
N-(Gly-Pro)-N'-(5-chloropentanoyl)-rhodamine 110 + H2O | - |
Homo sapiens | Gly-Pro + N-(5-chloropentanoyl)-rhodamine 110 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CD26 | - |
Homo sapiens |
dipeptidyl peptidase IV | - |
Homo sapiens |
DP IV | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics | Homo sapiens | |
0.002 | - |
human HIV-1 Trp2-Tat(1-9) peptide | pH 7.6, 30°C, recombinant, soluble enzyme | Homo sapiens | |
0.005 | - |
thromboxane A2 receptor peptide TXA2-R(1-9) | pH 7.6, 30°C, recombinant, soluble enzyme | Homo sapiens | |
0.012 | - |
Met-Trp1-G-CSF(1-8) peptide | pH 7.6, 30°C, recombinant, soluble enzyme | Homo sapiens | |
0.016 | - |
interleukin-2 peptide Met-TRp1-IL-2(1-8) | pH 7.6, 30°C, recombinant, soluble enzyme | Homo sapiens | |
0.025 | - |
Met-Trp-Pro | pH 7.6, 30°C, recombinant, soluble enzyme | Homo sapiens | |
0.043 | - |
human HIV-1 Lys2-Tat(1-9) peptide | pH 7.6, 30°C, recombinant, soluble enzyme | Homo sapiens | |
0.044 | - |
Trp2,Ile3-Tat(1-9) peptide | pH 7.6, 30°C, recombinant, soluble enzyme | Homo sapiens | |
0.15 | - |
human HIV-1 Trp1-Tat(1-9) peptide | pH 7.6, 30°C, recombinant, soluble enzyme | Homo sapiens | |
0.2 | - |
Met-Trp-Val | pH 7.6, 30°C, recombinant, soluble enzyme | Homo sapiens | |
0.23 | - |
human HIV-1 Tat(1-9) peptide | pH 7.6, 30°C, recombinant, soluble enzyme, versus substrate Gly-Pro-rhodamine R110-CO-(CH2)4Cl | Homo sapiens | |
0.267 | - |
human HIV-1 Tat(1-9) peptide | pH 7.6, 30°C, recombinant, soluble enzyme | Homo sapiens | |
0.269 | - |
interleukin-2 peptide Met-IL-2(1-12) | pH 7.6, 30°C, recombinant, soluble enzyme | Homo sapiens | |
0.487 | - |
human HIV-1 Gly3-Tat(1-9) peptide | pH 7.6, 30°C, recombinant, soluble enzyme | Homo sapiens | |
1.75 | - |
human HIV-1 Ile3-Tat(1-9) peptide | pH 7.6, 30°C, recombinant, soluble enzyme | Homo sapiens |