KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glucagon-like peptide 1 + H2O | Homo sapiens | i.e. GLP-1, incretin, degradation, regulation of activity | ? | - |
? | |
glucose-dependent insulinotropic polypeptide + H2O | Homo sapiens | i.e. GIP, incretin | ? | - |
? | |
additional information | Homo sapiens | substrate specificty | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline | enzyme prefers Ala in P1 position, reduced activity is observed with Ser, Gly, or Val at the P1 position, modeling of reaction mechanism and substrate binding at the catalytic site | Homo sapiens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glucagon-like peptide 1 + H2O | i.e. GLP-1, incretin, degradation, regulation of activity | Homo sapiens | ? | - |
? | |
glucose-dependent insulinotropic polypeptide + H2O | i.e. GIP, incretin | Homo sapiens | ? | - |
? | |
glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O | GIP-fragment | Homo sapiens | ? | - |
? | |
glucose-dependent insulinotropic polypeptide(1-42) peptide + H2O | GIP-fragment | Homo sapiens | ? | - |
? | |
glucose-dependent insulinotropic polypeptide(1-6) peptide + H2O | GIP-fragment, very low activity | Homo sapiens | ? | - |
? | |
additional information | substrate specificty | Homo sapiens | ? | - |
? | |
additional information | substrate specificty, no activity with glucose-dependent insulinotropic polypeptide(3-42) peptide, [Gly2]glucose-dependent insulinotropic polypeptide(1-6) peptide, and [Val2]glucose-dependent insulinotropic polypeptide(1-6) peptide | Homo sapiens | ? | - |
? | |
[Gly2]glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O | GIP-fragment with glycine at position 2 in the sequence | Homo sapiens | ? | - |
? | |
[Ser2]glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O | GIP-fragment with serine at position 2 in the sequence | Homo sapiens | ? | - |
? | |
[Ser2]glucose-dependent insulinotropic polypeptide(1-6) peptide + H2O | GIP-fragment with serine at position 2 in the sequence | Homo sapiens | ? | - |
? | |
[Val2]glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O | GIP-fragment with valine at position 2 in the sequence | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CD26 | - |
Homo sapiens |
dipeptidyl peptidase IV | - |
Homo sapiens |
DP IV | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Homo sapiens |