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Literature summary for 3.4.14.5 extracted from

  • Lambeir, A.M.; Rea, D.; Fulop, V.; Kumagai, Y.; Augustyns, K.; De Meester, I.; Haemers, A.; Scharpe, S.
    Exploration of the active site of dipeptidyl peptidase IV from Porphyromonas gingivalis: comparison with the human enzyme (2003), Adv. Exp. Med. Biol., 524, 29-35.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-(L-alanyl)pyrrolidine reversible Homo sapiens
1-(L-alanyl)pyrrolidine reversible Porphyromonas gingivalis
1-(L-cyclohexylalanyl)piperidine reversible Homo sapiens
1-(L-cyclohexylalanyl)piperidine reversible Porphyromonas gingivalis
1-(L-cyclohexylalanyl)pyrrolidine reversible Homo sapiens
1-(L-cyclohexylalanyl)pyrrolidine reversible Porphyromonas gingivalis
1-(L-isoleucyl)-1,2,5,6-tetrahydropyridine reversible Homo sapiens
1-(L-isoleucyl)-1,2,5,6-tetrahydropyridine reversible Porphyromonas gingivalis
1-(L-isoleucyl)-3(R,S)-azidopyrrolidine reversible Homo sapiens
1-(L-isoleucyl)-3(R,S)-azidopyrrolidine reversible Porphyromonas gingivalis
1-(L-isoleucyl)-3(R,S)-chloropyrrolidine reversible Homo sapiens
1-(L-isoleucyl)-3(R,S)-chloropyrrolidine reversible Porphyromonas gingivalis
1-(L-isoleucyl)-3(R,S)-hydroxypyrrolidine reversible Homo sapiens
1-(L-isoleucyl)-3(R,S)-hydroxypyrrolidine reversible Porphyromonas gingivalis
1-(L-isoleucyl)-3-pyrroline reversible Homo sapiens
1-(L-isoleucyl)-3-pyrroline reversible Porphyromonas gingivalis
1-(L-isoleucyl)hexamethyleneimine reversible Homo sapiens
1-(L-isoleucyl)hexamethyleneimine reversible Porphyromonas gingivalis
1-(L-isoleucyl)piperidine reversible Homo sapiens
1-(L-isoleucyl)piperidine reversible Porphyromonas gingivalis
1-(L-isoleucyl)pyrrolidine reversible Homo sapiens
1-(L-isoleucyl)pyrrolidine reversible Porphyromonas gingivalis
1-(L-lysyl)piperidine reversible Homo sapiens
1-(L-lysyl)piperidine reversible Porphyromonas gingivalis
1-(L-lysyl)pyrrolidine reversible Homo sapiens
1-(L-lysyl)pyrrolidine reversible Porphyromonas gingivalis
1-(L-phenylalanyl)pyrrolidine reversible Homo sapiens
1-(L-phenylalanyl)pyrrolidine reversible Porphyromonas gingivalis
1-(L-prolyl)pyrrolidine reversible Homo sapiens
1-(L-prolyl)pyrrolidine reversible Porphyromonas gingivalis
1-(L-tyrosyl)pyrrolidine reversible Homo sapiens
1-(L-tyrosyl)pyrrolidine reversible Porphyromonas gingivalis
1-(L-valyl)pyrrolidine reversible Homo sapiens
1-(L-valyl)pyrrolidine reversible Porphyromonas gingivalis
bis(4-acetamidophenyl) 1-((S)-prolyl)pyrrolidine-2(R,S)-phosphonate i.e. AB192 Homo sapiens
bis(4-acetamidophenyl) 1-((S)-prolyl)pyrrolidine-2(R,S)-phosphonate i.e. AB192 Porphyromonas gingivalis
bis(4-[(ethoxycarbonyl)-methylaminocarbonyl]-phenyl) 1-((S)-prolyl)pyrrolidine-2-(R,S)-phosphonate i.e. AB207 Homo sapiens
bis(4-[(ethoxycarbonyl)-methylaminocarbonyl]-phenyl) 1-((S)-prolyl)pyrrolidine-2-(R,S)-phosphonate i.e. AB207 Porphyromonas gingivalis

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Porphyromonas gingivalis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-Pro-4-nitroanilide + H2O
-
Porphyromonas gingivalis Ala-Pro + 4-nitroaniline
-
?
Ala-Pro-4-nitroanilide + H2O high activity Homo sapiens Ala-Pro + 4-nitroaniline
-
?
Asn-Pro-4-nitroanilide + H2O
-
Homo sapiens Asn-Pro + 4-nitroaniline
-
?
Asn-Pro-4-nitroanilide + H2O poor substrate Porphyromonas gingivalis Asn-Pro + 4-nitroaniline
-
?
Asp-Pro-4-nitroanilide + H2O low activity Homo sapiens Asp-Pro + 4-nitroaniline
-
?
Gly-Ala-4-nitroanilide + H2O poor substrate Porphyromonas gingivalis Gly-Ala + 4-nitroaniline
-
?
Gly-Ala-4-nitroanilide + H2O low activity Homo sapiens Gly-Ala + 4-nitroaniline
-
?
Gly-Pro-4-nitroanilide + H2O
-
Homo sapiens Gly-Pro + 4-nitroaniline
-
?
Gly-Pro-4-nitroanilide + H2O low activity Porphyromonas gingivalis Gly-Pro + 4-nitroaniline
-
?
His-Ala-4-nitroanilide + H2O
-
Homo sapiens His-Ala + 4-nitroaniline
-
?
His-Ala-4-nitroanilide + H2O poor substrate Porphyromonas gingivalis His-Ala + 4-nitroaniline
-
?
His-Pro-4-nitroanilide + H2O
-
Homo sapiens His-Pro + 4-nitroaniline
-
?
His-Pro-4-nitroanilide + H2O low activity Porphyromonas gingivalis His-Pro + 4-nitroaniline
-
?
Ile-Pro-4-nitroanilide + H2O
-
Homo sapiens Ile-Pro + 4-nitroaniline
-
?
Ile-Pro-4-nitroanilide + H2O low activity Porphyromonas gingivalis Ile-Pro + 4-nitroaniline
-
?
Lys-Ala-4-nitroanilide + H2O
-
Homo sapiens Lys-Ala + 4-nitroaniline
-
?
Lys-Ala-4-nitroanilide + H2O
-
Porphyromonas gingivalis Lys-Ala + 4-nitroaniline
-
?
Lys-Pro-4-nitroanilide + H2O
-
Homo sapiens Lys-Pro + 4-nitroaniline
-
?
Lys-Pro-4-nitroanilide + H2O
-
Porphyromonas gingivalis Lys-Pro + 4-nitroaniline
-
?
additional information substrate specificity Homo sapiens ?
-
?
additional information substrate specificty Porphyromonas gingivalis ?
-
?
Phe-Ala-4-nitroanilide + H2O
-
Homo sapiens Phe-Ala + 4-nitroaniline
-
?
Phe-Pro-4-nitroanilide + H2O
-
Homo sapiens Phe-Pro + 4-nitroaniline
-
?
Phe-Pro-4-nitroanilide + H2O low activity Porphyromonas gingivalis Phe-Pro + 4-nitroaniline
-
?
Pro-Ala-4-nitroanilide + H2O
-
Porphyromonas gingivalis Pro-Ala + 4-nitroaniline
-
?
Pro-Ala-4-nitroanilide + H2O best substrate Homo sapiens Pro-Ala + 4-nitroaniline
-
?
Pro-Pro-4-nitroanilide + H2O
-
Porphyromonas gingivalis Pro-Pro + 4-nitroaniline
-
?
Pro-Pro-4-nitroanilide + H2O high activity Homo sapiens Pro-Pro + 4-nitroaniline
-
?
Ser-Pro-4-nitroanilide + H2O
-
Homo sapiens Ser-Pro + 4-nitroaniline
-
?
Ser-Pro-4-nitroanilide + H2O low activity Porphyromonas gingivalis Ser-Pro + 4-nitroaniline
-
?
Tyr-Ala-4-nitroanilide + H2O
-
Homo sapiens Tyr-Ala + 4-nitroaniline
-
?
Tyr-Ala-4-nitroanilide + H2O poor substrate Porphyromonas gingivalis Tyr-Ala + 4-nitroaniline
-
?
Tyr-Pro-4-nitroanilide + H2O
-
Homo sapiens Tyr-Pro + 4-nitroaniline
-
?
Tyr-Pro-4-nitroanilide + H2O
-
Porphyromonas gingivalis Tyr-Pro + 4-nitroaniline
-
?
Val-Pro-4-nitroanilide + H2O
-
Homo sapiens Val-Pro + 4-nitroaniline
-
?
Val-Pro-4-nitroanilide + H2O best substrate Porphyromonas gingivalis Val-Pro + 4-nitroaniline
-
?

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase IV
-
Homo sapiens
dipeptidyl peptidase IV
-
Porphyromonas gingivalis
DPP IV
-
Homo sapiens
DPP IV
-
Porphyromonas gingivalis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information
-
Porphyromonas gingivalis